Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5

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Powder: Yes
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  • Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5
  • Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5
  • Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5
  • Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5
  • Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5
  • Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5
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Basic Info.

Model NO.
BP/USP/FCC
Certification
ISO 9001, USP, BP
Suitable for
Children, Adult
State
Solid
Purity
>96%
Store
Dry and Coold Place
CAS No.
128446-35-5
M F
C63h112o42
M G
1541.54
En No.
420-920-1
Transport Package
25kg/Drum
Specification
BP/USP/FCC
Trademark
JK
Origin
China
HS Code
294000
Production Capacity
100mt/Year

Product Description

Hydroxypropyl Betadex is the hydroxyalkylation derivative of Beta Cyclodextrin. Hydroxypropyl Betadex is non-toxic and has no side-effect. Due to its unique structure, it can improve the solubility of drugs, and making the insoluble and the indissolvable drugs dissolved in water. Consequently, it can effectively improve the bioavailability of drugs, and significantly increase the quality of medicine and dosage form. And it is widely used in the development and manufacture of new drugs.

There has been intensive and deep research on the quality, manufacturing process, stability, pharmacology, toxicology, teratogenesis, mutagenesis, carcinogenicity, hemolysis, irritation and other aspects in world, and has obtained accurate evaluation of its safety. It is safe to conclude that derivative of cyclodextrin is the pharmaceutic excipients received the most intensive research, having the most comprehensive information, and having the highest value in medicine excipients.
 

ASSAY EP USP
Appearance White or almost white, amorphous or crystalline powder White or almost white, amorphous or crystalline powder
Clarity of solution See EP9.0 See USP40-NF35
Loss on drying Maximum 10.0% NMT 10.0%
Heavy metals   NMT 20μg/g
Betadex Maximum 1.5% NMT 1.5%
Propyne glycol Maximum 2.5% NMT 2.5%
Any other single impurity   NMT 0.25%
Total impurities excluding betadex and prolene glycol Maximum 1.0% NMT 1.0%
Methyl ethylnexide   NMT 0.0001%
Molar substitution Molar substitution 0.40-1.50 Molar substitution 0.40-1.50
Conductivity Maximum 200μA.CM∧-1 Maximum 200μA.CM∧-1
Microbial limit Corporate internal control standards
The total aerobic microbial count ≤100CFU/g
The total combined molds and yeasts count ≤10CFU/g
Escherichia coli Not detectable
Bacterial endotoxins <10IU/g

 

Natural Cyclodextrin;
Alpha-Cyclodextrin Beta-Cyclodextrin Gamma-Cyclodextrin
Alpha Cyclodextrin   Derivatives;
Hydroxypropyl-Alpha-Cyclodextrin Sulfobutylether-Alpha-Cyclodextrin
Beta  Cyclodextrin    Derivatives;  
Hydroxypropyl-Beta-Cyclodextrin Sulfobutyl ether-Beta-Cyclodextrin Sodium
Piroxicam-Beta-Cyclodextrin Glucosyl-Beta-Cyclodextrin
Hydroxyethyl-Beta-Cyclodextrin Carboxymethyl-Beta-Cyclodextrin
Hydroxypropyl-Beta-Cyclodextrin 2,6-Dimethyl-Beta-Cyclodextrin
2-Hydroxypropyl-Beta-Cyclodextrin Methyl-Beta-Cyclodextrin
Gamma Cyclodextrin   Derivatives;
Hydroxypropyl-Gamma-Cyclodextrin Sulfobutylether-Gamma-Cyclodextrin
Cyclodextrin Inclusion Compounds
Soluble inclusion compound of pueraria flavones Soluble inclusion compound of Gynostemma Extract
Plant essential oil inclusion compound Flavor inclusion compound
Rotation substance separation reagent
Chromatogram filler: cyclodextrins.



Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5

 

2-Hydroxypropyl-β-cyclodextrin Basic information
Product Name: 2-Hydroxypropyl-β-cyclodextrin
Synonyms: Hydroxypropyl beta cyclodextrin aqueous solution;Injection grade hydroxypropyl betadex;Pharmaceutical grade hydroxypropyl betadex;Technical grade hydroxypropyl beta cyclodextrin;HPBCD\/(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN;beta-hydroxypropylcyclodextrin;(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN;(2-Hydroxypropyl)-β-cyclodextrin
CAS: 128446-35-5
MF: C63H112O42
MW: 1541.54
EINECS: 420-920-1
Product Categories: Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Chelation/Complexation Compounds;Synthetic Reagents;CyclodextrinsCell Culture;CyclodextrinsSynthetic Reagents;Cell Signaling and Neuroscience;Lipids and Lipid Carriers;Reagents and Supplements;Signal Transduction Research Tools;Carbohydrates & Derivatives;Other APIs
Mol File: 128446-35-5.mol
 
 
2-Hydroxypropyl-β-cyclodextrin Chemical Properties
Melting point  278 °C (dec.)
refractive index  125 ° (C=1, H2O)
storage temp.  2-8°C
solubility  H2O: 45 % (w/v)
form  solution (clear, colorless)
color  White to slightly yellow
optical activity [α]26/D +139°, c = 1 in H2O
Water Solubility  Soluble in water.
InChIKey ODLHGICHYURWBS-FOSILIAISA-N
EPA Substance Registry System .beta.-Cyclodextrin, 2-hydroxypropyl ethers (128446-35-5)
 
Safety Information
Safety Statements  24/25
WGK Germany  3
RTECS  GU2293332
TSCA  Yes
HS Code  29400090
 
 
2-Hydroxypropyl-β-cyclodextrin Usage And Synthesis
Chemical Properties White to slightly yellow powder
Chemical Properties Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.
Uses 2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.
Uses enteric coating, sustained release formulations, buccal and transdermal drug delivery
Uses 2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis
Production Methods Hydroxypropyl betadex is prepared by the treatment of an alkaline solution of b-cyclodextrin with propene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.
Pharmaceutical Applications Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations.
Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.
Safety The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability.
storage Store in well-closed containers.
Regulatory Status Included in oral and parenteral medicinal products. Included in an injectable preparation licensed in the UK for intramuscular or intravenous administration.




Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on.
Our food additives and food ingredients, especially our Ascorbic Acid (Vitamin C), Acesulfame-K, Aspartame, Citrates, Dextrose, D-Xylose, Erythorbic Acid, Fumaric Acid, Fructose,Maltodextrin, Malic Acid, Monosodium glutamate, Lactic Acid Potassium Sorbate, Sodium Erythorbate, Sodium Cyclamate, Sodium Saccharin, sodium benzoate, Sodium ascorbate, Sorbic Acid, xanthan Gum, Xylitol, Tartaric Acid, I+G, , Vanillin, Sucralose, Stevia and so on, have been exported to more than 60 countries for our good quality products.
Our staff of sales and technical support is available to help you in selecting the right protection for your application as well as to provide you with samples of our products for evaluation. At High Five, we are committed to providing the highest level of customer service, competitive pricing, speedy delivery and a comprehensive, cutting-edge product offering. Our ultimate goal is your satisfaction.





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Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5
FAQ

Q1.What's the payment terms?
We could accept T/T, L/C, DP payment terms.

Q2.How about the different index of products in same application?
Specifications can be customized according to your application.

Q3.How about the samples of products?
We can provide free samples under 2Kg(not including freight charge).

Q4.How about the price of products?
Our products are chemical synthesis got from underground brine, which is available for a variety of usage. Our products are high purity with good quality, and the price is based on different specification and quantity.

Q5.What's the shelf life for the cargoes?
Our product's shelf life is 2 years, which is based on dry and ventilated storage.

Q6.What's the package of the cargoes?
20kg/25kg woven bags, within plastic bags, or as customized.

Q7.What's the delivery time?
We usually deliver the cargoes within 10~20 days after receiving customer's payment or original L/C.


Q8.Which documents can we supply?
Commercial Invoice, Packing List, Certificate of Analysis, Certificate of Origin (FORM E), Bill of Loading, ISO etc.
The documents will be sent by Express within 24 hours against your full payment.

Q9.Why do you choose us?
We accept safe and diversified payment terms.
We supply a price trend to ensure clients know marketing information in time. We will take charge of 100% responsibility for
quality issue. We strive to create value for each customer we serve by meeting their unique needs and providing solutions to solve their problems and achieve their objectives.









Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5Hydroxypropyl Beta Cyclodextrin CAS No. 128446-35-5







 

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