Huperzine a and (-) -Huperzine a

• Powder: Yes
• Customized: Non-Customized
• Certification: ISO 9001
• Suitable for: Children, Adult
• State: Solid
• Purity: ≦96%
• Model NO.: food grade
• Test Method: HPLC
• Store: Dry and Cool Place
• CAS No.: 120786-18-7
• M F: C15h18n2o
• M G: 242.32
• CAS No. 2: 102518-79-6
• En No.: 600-320-6
• Transport Package: 25kg/Drum
• Specification: Food grade
• Trademark: JK
• Origin: China
• HS Code: 1302199099
• Production Capacity: 100mt/Year

Product Description

High quality 99% Huperzine-A
Product Description
[Product Name]       Huperzine A
[Other Name]           Huperzia serrata extract
[Botanical Source]   Huperzia serrata(Thunb. ex Murray) Trevis.
[Part Used]               The whole herb
[Specification]          1~99%
[Test Method]          HPLC
[Color]                     White/brown
[CAS No.]                102518-79-6

Examination Items	Examination Standards	Results
[Description]
Appearance     Extract Solvents	White crystalline powder   Soluble in Menol; Partly soluble in Ethanol; Insoluble in water	Complies   Complies Complies
[Inspection]
Alkaloid identification	Positive reaction	Complies
Loss on Drying	4.0% max	2.6%
Ash   Related Substances	1.0% max   Totle area of impurities in the  test solution must be less then  the area of main leap in the  reference solution	0.27%   Complies
Heavy Metals	10ppm max	Complies
Arsenic	2ppm max	Complies
[Microbiological Inspection]
Total Bacterial Count	1000cfu/g max	Conformed
Total Yeasts and Molds	100cfu/g max	32cfu/g max
E. Coli	Negative	Not Detected
Salmonella	Negative	Not Detected
[Content Assay]
Huperzine-A	99% min ( By HPLC)	99.1

Huperzia Serrata Extract

Product Name: Huperzia Serrata Extract 
Botanical Source: Lycopodium serratum Thunb. 
Part Used: Whole Herb 
Specification: 1%~99%Huperzine A 
Appearance: Brown White Powder

Description

Huperzia Serrata is a type of firmoss that contain the memory-boosting nootropic compound Huperzine A.
 
This acetylcholinesterase inhibitor is known for increasing levels of a neurotransmitter related to memory formation, recall and many of the most basic cognitive functions.
 
The plant itself is also known as Chinese club moss and is native to India and Southeast Asia. The extract of this plant has been used in the traditional medicine of China for centuries.
 
Huperzia Serrata is widely distributed over the counter as both an herbal Alzheimer's treatment and as a cognitive enhancement supplement. You will find Huperzia Serrata in supplements such as Alpha Brain while most other Huperzine A sources use synthetic versions of this alkaloid.

 Main Function

1. A cure for nonmalignant memory disorder and organic mental disorders
2. A cure for cerebrovascular disease and brain trauma
3. Acure for peripheral arterial occlusion disease and diabetic neuropathy
4. Acure for Achilles tendon pains and muscle trauma in sports

 Application Filed

1. As pharmaceutical raw materials for clearing heat, anti-inflammation, detumescence and so on, it is mainly used in pharmaceutical field;
2. As the raw material of product for benefiting stomach, increasing energy and boosting the immunity, widely used in health industry.

 

Huperzine A Basic information

Product Name:	Huperzine A
Synonyms:	(11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one;(+/-)-HUPERAZINE A;HUPERAZINE A;(+/-)-HUPERZINE A;HUPERZINE A;1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one;(±)-Huperzine A, >98%;(+/-)-SELAGINE
CAS:	120786-18-7
MF:	C15H18N2O
MW:	242.32
EINECS:
Product Categories:	Natural Plant Extract;Acetylcholine receptor;Herb extract
Mol File:	120786-18-7.mol

Huperzine A Chemical Properties

Boiling point	505.0±50.0 °C(Predicted)
density	1.20±0.1 g/cm3(Predicted)
storage temp.	2-8°C
form	Off-white solid.
pka	12.25±0.60(Predicted)
CAS DataBase Reference	120786-18-7

Safety Information

Hazard Codes	T
Risk Statements	23/24/25-36/37/38
Safety Statements	26-36/37/39-45
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
RTECS	PB9185700

MSDS Information

Provider	Language
SigmaAldrich	English

Huperzine A Usage And Synthesis

Occurrence	Huperzine A is a synthetic.
Uses	Huperzine A is used for dementia in Alzheimer's disease and for muscle weakness in myasthenia gravis.

 

(-)-Huperzine A Basic information

Huperzia serrata extract Acetylcholinesterase Indications Side effects Inhibition HPLC determination of the content of Huperzine A Uses

Product Name:	(-)-Huperzine A
Synonyms:	(+-)-huperzine A,Huperzine-a,Huperzine A;Huperzine A 102518-79-6;HUP, [5R-(5a,911E)]-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2-(1H)-one, Selagine,;5,9-Methanocyclooctabpyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)-;HUPERZINE A 1%;Huperzine A ( Selagine );(-)-HUPERZINE A, 99% HPLC;(-)-Huperzine A
CAS:	102518-79-6
MF:	C15H18N2O
MW:	242.32
EINECS:	600-320-6
Product Categories:	Alkaloids;API;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;Nutritional Ingredients;reference substance;Inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;TCI
Mol File:	102518-79-6.mol

(-)-Huperzine A Chemical Properties

Melting point	211-216oC
alpha	D -147° (c = 0.36 in CH3OH) (Ayer); D24.5 -150.4° (c = 0.498 in MeOH) (Liu)
Boiling point	505.0±50.0 °C(Predicted)
density	1.20±0.1 g/cm3(Predicted)
storage temp.	?20°C
pka	12.25±0.60(Predicted)
form	neat
optical activity	[α]/D -153±5°, c = 0.5 in metol
CAS DataBase Reference	102518-79-6(CAS DataBase Reference)

Safety Information

Hazard Codes	T+
Risk Statements	26/27/28-36/37/38
Safety Statements	26-36/37/39-45
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
RTECS	PB9185700
HS Code	29339900

MSDS Information

Provider	Language
SigmaAldrich	English

(-)-Huperzine A Usage And Synthesis

Huperzia serrata extract	Huperzine A is a natural plant alkaloid that extracted from the Chinese medicine Huperzia serrata under the genus Huperzia. It is a potent, revisable and highly selective second generation of acetylcholinesterase inhibitors, with the appearance of yellow to white crystalline powder, and is freely soluble in chlor, soluble in methl and ethanol, slightly soluble in water, with high lipid solubility. It is a small molecule that can well penetrate the blood brain barrier, and after entering the central nervous, it distributes more in the brain's frontal lobe, temporal lobe, hippocampus and areas that are closely related to learning and memory. It has a strong inhibitory effect on acetylcholinesterase (AchE) at a low dosage, significantly increasing the content of acetylcholine (Ach) in neural synaptic cleft in the distribution area, thus enhancing neuronal excitatory transmission, strengthening the excitement of learning and memory in the brain, thereby with the function of improving cognitive function, enhancing memory retention and promoting memory reproduction. It is currently the most successful development of Alzheimer's disease (senile dementia) drugs. The above information is edited by the Chemicalbook of Cheng Jingmin.
Acetylcholinesterase	AChE is an enzyme in the brain to decompose the neurotransmitter acetylcholine, responsible for function of a large number of neurons synaptic and excitability of the central nervous system. An acetylcholinesterase molecule can reduce functions of about 25000 acetylcholine molecule. Such inhibitor is often used as nerve gas agent, because too much acetylcholine in the body can cause muscle paralysis and suffocation.  Patients with Alzheimer's disease often lack acetylcholine, because acetylcholine plays an important role in nerve stimulation, memory and learning, as well as excitement. The decrease of Acetylcholinesterase levels can release acetylcholine, making more neurons active.
Indications	Huperzine A is a potent reversible cholinesterase inhibitor, stronger than physostigmine, neostigmine and Tacrine. When used for myasthenia gravis, the effective rate reaches to 99%.  Clinical trials show that the product is suitable for benign memory disorders. It can improve patients' ability in directed memory, associative learning, image memory, meaningless figure recognition and portrait retrieval,and it also can enhance normal people's ability in learning and memory. This product also can improve memory disorders that caused by dementia and organic pathologic changes in brain.  Clinically, Huperzine A is applicable to the treatment of the following symptoms: 1. for the treatment and improvement of memory dysfunction in elder age, improving memory association function; for the memory deterioration caused by excessive use of the brain, improving work efficiency; 2. for memory function deterioration associated with neurasthenia; 3. for memory deterioration caused by cerebral vascular disorder; 4. for memory improvement of Alzheimer's disease, and it has significant effects on improving and restoring the patient's cognitive ability, memory function and abnormal emotion behaviors; 5. for the treatment of myasthenia gravis; 6. for improvement of disturbance of association, low cognitive function, memory deterioration that associated with schizophrenia; 7. for improvement of memory dysfunction associated with a variety of brain diseases and physical disorders.
Side effects	Skin hives, abdominal pain, salivation, muscle twitching, diarrhea, and insomnia, but not common.  Overdose can cause dizziness, nausea, gastrointestinal discomfort, chest tightness, fatigue, bradycardia and other reactions. The symptoms usually disappear on their own, and relief or disappear after stopping or reduction of the product when reacting significantly.
Inhibition	Huperzine A has selective inhibition for true cholinesterase, and the inhibition strength is thousands of times stronger than pseudocholinesterase. The suppression mode is mixed inhibition of competitive and noncompetitive, with significant differences with pure competitive inhibitors. This product crosses the blood-brain barrier into the central nervous easily, having both central and peripheral therapeutic effects; it has a long effective time; it is well absorbed from the gastrointestinal tract; it has large safety index; it has good stability.  The comparison result of inhibition intensity of different drugs to acetylcholinesterase (AChE): Huperzine A> physostigmine> neostigmine> Huperzine B> galantamine> galanin.  The inhibition strength to human butyrylcholinesterase (BuChE): physostigmine> neostigmine> Huperzine A> Huperzine B. The functions of this product in both strengthening muscle contraction amplitude that induced by indirect electrical nerve stimulation and enhancing memory in rats are stronger than physostigmine, but its toxicity is lower than physostigmine, and it has longer duration of effectiveness.
HPLC determination of the content of Huperzine A	[The test] Capsules that processed by extracts of Huperzia serrata (Thunb) Trev (Huperziaceae).  1. Chromatographic conditions: Column: Alltima C18 column (4.6mm × 150mm), mobile phase: metol-0.1mol/L ammonium acetate buffer (pH6.0) (36:64); flow rate: 0.6ml/min; detection wavelength: 308nm; column temperature: room temperature.  2. The preparation of the reference solution: take defined amount of the reference substance of Huperzine A, add it to the mobile phase to make the reference solution with 0.005mg reference substance per ml.  3. Preparation of sample solution: Take the contents of Huperzine A capsules (the equivalent of 0.125mg huperzine A) to a 25ml flask, and use the mobile phase to melt and dilute to volume, and shake and take it as the sample solution. 4.Determination: take the reference and sample solution 20μl respectively and do the injection analysis.
Uses	This product can effectively prevent the debilitating brain in elder age, restore brain function, active brain neurotransmitter substances, and it is the new drug for the treatment of benign memory impairment currently.  Huperzine A can not only inhibite the activity of cholinesterase, but also improve cognitive function and ability of learning and memory through a variety of pharmacological mechanisms like effecting the system of free radicals, reducing expression levels of somatostatin, intracellular [Ca2+], glutamic acid content and increase calmodulin (CaM) and calmodulin messenger RNA (CaM mRNA).
Chemical Properties	Pale Brown Solid
Uses	Reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. A potential therapeutic agent for Alzheimer's disease. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cerebellum of embryonic rat brain.
Uses	anticholinesterase, cognition enhancer
Uses	cognition-enhancing activity, potential Alzheimer's therapeutic
Uses	Reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. A potential therapeutic agent for Alzheimer disease. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cere
Definition	ChEBI: A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity.

Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on. 
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