Erythritol CAS. No. 149-32-6 E968 Acesulfame K

• CAS No.: 149-32-6
• Formula: C4h10o4
• EINECS: 22839-47-0
• Type: Sweetener
• Nutritional Value: Nutritional
• Effect: Sweetener
• Model NO.: E968, FCC
• Resource: Natural
• Store: Dry and Cool Place
• En. No.: E968
• M G: 122.12
• Delivery: 15days
• Loading Port: Qingdao
• Loading Port 2: Shanghai
• Transport Package: 25kg/Bag
• Specification: Food grade
• Trademark: JK
• Origin: China
• HS Code: 294000
• Production Capacity: 1000mt/Month

Product Description

Erythritol is a very popular sweetener, which is unique natural polyol sweeteners with non calorie and clear cool mouth feel.
Erythritol is a polyol (sugar alcohol) which is very popular for use in baking and as a general sweetener in low carb diets.
Erythritol, as alternatives to sugars and as part of a comprehensive program including proper dental hygiene has been recognized by the American dental association.

Characteristics of Erythritol:
1. Low in calories:
Erythritol has a very low caloric content; Its value is 0.2 calories per gram for food labeling purposes in the United States and 0 (zero) calories per gram for food labeling purposes in Japan. This very low calorie value is due to erythritol's unique absorption and elimination process which does not require the metabolism of erythritol. Thus, erythritol is uniquely qualified as a very low calorie bulk sweetener for formulating light and reduced calorie products which require a 25% or more calorie reduction from the standard formulation.

2. High digestive tolerance:
Erythritol is rapidly absorbed in the small intestine due to its small molecular size and structure. Several clinical studies conducted in Europe and Japan have shown that more than 90% of ingested erythritol is absorbed and excreted unchanged in urine within a 24-hour period. This digestive pathway allows less than 5% of ingested erythritol to reach the large intestine and be fermented into volatile fatty acids or metabolized into carbon dioxide. As a result, foods containing substantial amounts of erythritol are very unlikely to cause gaseous and laxation side effects. A recent clinical study concluded daily consumption of 1 gram per kilogram body weight is well tolerated by adults as compared to sucrose containing foods.

3. Safe for diabetes' person:
Single dose and 14-day clinical studies demonstrate erythritol does not affect blood serum glucose or levels. Clinical studies conducted in people with diabetes conclude that erythritol may be safely used to replace sucrose in foods formulated specifically for people with diabetes. Of course, those with diabetes should consider the impact on their diet of other ingredients used in foods sweetened with erythritol.

4. Does not cause tooth decay:
Erythritol like other polyols is resistant to metabolism by oral bacteria which break down sugars and starches to produce acids which may lead to tooth enamel loss and cavities formation. They are, therefore, non-cariogenic. The usefulness of polyols, including

Application:
Widely used in drinks, candy, cake, chocolate, bakery products, table sugar etc.

Appearance	White crystal powder
Melting range	118-122
PH	5.0-7.0
Loss on drying	≤0.2%
Ash	≤0.01%
Heavy metals	≤5mg/kg
Assay	≥98.0%
Arsenic	≤2.0 mg/kg
Cont of bacteria	≤300 cfu/g
Coliform	Negative

 

Product Name:	Erythritol
Synonyms:	4-[[17-[(E)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-oxobutanoic acid;Rheum glycol;Erythritol Threitol;tetritol;MESO-EYTHRITOL;1,2,3,4-Butanetetrol, meso-1,2,3,4-Tetrahydroxybutane, i-Erythritol;(2R,3S)-1,2,3,4-Butanetetrol;Erithrite
CAS:	149-32-6
MF:	C4H10O4
MW:	122.12
EINECS:	205-737-3
Product Categories:	Sugars, Carbohydrates & Glucosides;Biochemistry;Erythrose;Sugar Alcohols;Sugars;Food & Flavor Additives;Food additive and sweetener;Inhibitors
Mol File:	149-32-6.mol

Erythritol Chemical Properties

Melting point	118-120 °C(lit.)
Boiling point	329-331 °C(lit.)
density	1,451 g/cm^3
FEMA	4819 | ?ERYTHRITOL
refractive index	1.4502 (estimate)
Fp	329-331°C
storage temp.	?20°C
solubility	H2O: 0.1 g/mL, clear to almost clear, colorless
pka	13.9(at 25ºC)
form	Crystalline Powder or Crystals
color	White to off-white
Water Solubility	soluble
Merck	14,3675
BRN	1719753
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	UNXHWFMMPAWVPI-ZXZARUISSA-N
CAS DataBase Reference	149-32-6(CAS DataBase Reference)
NIST Chemistry Reference	2(r),3(s)-1,2,3,4-Butanetetrol(149-32-6)
EPA Substance Registry System	Erythrol (149-32-6)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	KF2000000
F	3-10
TSCA	Yes
HS Code	29054910
Toxicity	LD50 in male, female rats (g/kg): 6.6, 9.6 i.v.; >16, >16 s.c.; 13.1, 13.5 orally (Munro)

MSDS Information

Provider	Language
Erythritol	English
SigmaAldrich	English
ACROS	English
ALFA	English

Erythritol Usage And Synthesis

Chemical Properties	white crystals or powder
Chemical Properties	Erythritol (meso-erythritol, meso-1,2,3,4-Tetrahydroxybutan) has been known for a long time. Its potential use as a bulk sweetener was, however, recognized rather late. Erythritol is a natural constituent of several foods and beverages in levels sometimes exceeding 1 g/kg. Its solubility in water is approximately 370 g/L at room temperature and increases with increasing temperature. Erythritol melts at 121 C and is stable up to more than 160 C and in a pH range from 2 to 10. Depending on the concentration used, erythritol is approximately 60 % as sweet as sucrose. It is noncariogenic and not metabolized in the human body which means that it is more or less calorie-free.  In the European Union, erythritol is approved as E 968 for a large number of food applications. It is GRAS in the United States and also approved in many other countries.
Chemical Properties	Erythritol is a sugar alcohol (polyol) that occurs as a white or almost white powder or granular or crystalline substance. It is pleasant tasting with a mild sweetness approximately 60-70% that of sucrose. It also has a high negative heat of solution that provides a strong cooling effect.
Uses	non-cariogenic, low-calorie (0.4 kcal/g) sweetener
Uses	Non-nutritive sweetener in beverages.
Uses	Erythritol is a sweetener (polyol) manufactured by fermentation of glucose, the glucose-rich substrate being obtained by the enzymatic hydrolysis of starch. it is 60-70% as sweet as sugar, has excellent heat and acid stability, a high digestive tolerance, and a caloric value of 0.2 kcal/g. it is the only polyol produced by fermentation. it can be used as a sugar replacement in confectioneries, beverages, and desserts.
Production Methods	Erythritol is a starch-derived product. The starch is enzymatically hydrolyzed into glucose which is turned into erythritol via a fermentation process, using osmophilic yeasts or fungi (e.g. Moniliella pollinis, or Trichosporonoides megachiliensis).
Definition	ChEBI: The meso-diastereomer of butane-1,2,3,4-tetrol.
Biotechnological Production	The synthesis of erythritol is rather difficult. One of the possibilities is the catalytic reduction of tartaric acid with Raney nickel, which does, however, also produce threitol, a diastereomere of erythritol that requires separation of both. Threitol may be isomerized which increases the yields of erythritol. Another chemical synthesis starts from butane-2-diol-1.4 which is reacted with chlorine in aqueous alkali to yield erythritol-2-chlorohydrin and can be hydrolyzed with sodium carbonate solution. Synthesis from dialdehyde starch in the presence of a nickel catalyst at high temperatures is also possible. Owing to the special physiological properties of erythritol, commercial interest increased with the discovery of an increasing number of microorganisms able to produce this substance. Today, the commercial production of erythritol is apparently only based on fermentation.  Erythrytitol fermentations mostly use osmophilic yeasts. Based on regulatory submissions for commercial production, T. megachiliensis, M. pollinis, and Y. lipolytica are used. It is also claimed that P. tsukubaensis and Aureobasidium sp. are used for commercial production.  Erythritol-producing microorganisms often produce other polyols such as ribitol. Nevertheless, some strains had a rather high yield of erythritol. A two-step fermentation of C. magnoliae on 400 g/L glucose resulted in a 41 % conversion rate and a productivity of 2.8 g/Lh. M. pollinis cultivated on glucose and several nitrogen sources yielded erythritol concentrations up to 175 g/L with a conversion rate of 43 %. Oxygen limitation resulted in ethanol formation, and nitrogen limitation in strong foaming. A mutant gave even better yields. Aerobically on glucose cultured P. tsukubaensis KN 75 produced 245 g/L of erythritol with an especially high yield of 61 %. The productivity was 2.86 g/Lh. Scale-up from 7-L laboratory fermenter to 50,000-L industrial scale resulted in productivities similar to the laboratory value.
Pharmaceutical Applications	Erythritol is a naturally occurring noncariogenic excipient used in a variety of pharmaceutical preparations, including in solid dosage forms as a tablet filler, and in coatings. It has also been investigated for use in dry powder inhalers.It is also used in sugar-free lozenges,and medicated chewing gum. Erythritol can also be used as a diluent in wet granulation in combination with moisture-sensitive drugs. In buccal applications, such as medicated chewing gums, it is used because of its high negative heat of solution which provides a strong cooling effect. Erythritol is also used as a noncaloric sweetener in syrups; it is used to provide sensorial profile-modifying properties with intense sweeteners; and it is also used to mask unwanted aftertastes. Erythritol is also used as a noncariogenic sweetener in toothpastes and mouthwash solutions.
Safety	Erythritol is used in oral pharmaceutical formulations, confectionery, and food products. It is generally regarded as a nontoxic, nonallergenic, and nonirritant material. However, there has been a case report of urticaria caused by erythritol. The low molecular weight of erythritol allows more than 90% of the ingested molecules to be rapidly absorbed from the small intestine; it is not metabolized and is excreted unchanged in the urine. Erythritol has a low caloric value (0.8 kJ/g). The WHO has set an acceptable daily intake of 'not specified' for erythritol. Erythritol is noncariogenic; preliminary studies suggest that it may inhibit the formation of dental plaque. In general, erythritol is well-tolerated; furthermore, excessive consumption does not cause laxative effects. There is no significant increase in the blood glucose level after oral intake, and glycemic response is very low, making erythritol suitable for diabetics. LD50 (mouse, IP): 8-9 g/kg LD50 (rat, IV): 6.6 g/kg LD50 (rat, oral): >13 g/kg
storage	Erythritol has very good thermal and chemical stability. It is nonhygroscopic, and at 25°C does not significantly absorb additional water up to a relative humidity (RH) of more than 80%. Erythritol resists decomposition both in acidic and alkaline media and remains stable for prolonged periods at pH 2-10.(10) When stored for up to 4 years in ambient conditions (20°C, 50% RH) erythritol has been shown to be stable.
Purification Methods	meso-Erythritol crystallises from distilled water or absolute EtOH and is dried at 60o in a vacuum oven. It sublimes at 110o in a high vacuum. It is optically inactive. [Jeans & Hudson J Org Chem 20 1565 1955, IR: Kuhn Anal Chem 22 276 1950, Beilstein 1 IV 2807.]
Incompatibilities	Erythritol is incompatible with strong oxidizing agents and strong bases.
Regulatory Status	GRAS listed. Accepted for use as a food additive in Europe.

Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on.
Our food additives and food ingredients, especially our Ascorbic Acid (Vitamin C), Acesulfame-K, Aspartame, Citrates, Dextrose, D-Xylose, Erythorbic Acid, Fumaric Acid, Fructose,Maltodextrin, Malic Acid, Monosodium glutamate, Lactic Acid Potassium Sorbate, Sodium Erythorbate, Sodium Cyclamate, Sodium Saccharin, sodium benzoate, Sodium ascorbate, Sorbic Acid, xanthan Gum, Xylitol, Tartaric Acid, I+G, , Vanillin, Sucralose, Stevia and so on, have been exported to more than 60 countries for our good quality products.
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