Gamma Cyclodextrin CAS No 17465-86-0 Cyclooctapentylose

• Customization: Available
• CAS No.: 17465-86-0
• Formula: C48h80o40
• Model NO.: food grade
• Resource: Chemosynthesis
• Store: Dry and Cool Place
• M F: C48h80o40
• M G: 1297.12
• En No.: 241-482-4
• Transport Package: 25kg/Drum
• Specification: Food grade
• Trademark: JK
• Origin: China
• HS Code: 294000
• Production Capacity: 100mt/Year

Product Description

Certificate of Analysis

Product Name	gamma cyclodextrin
Batch No.	20200625	Invoice Date.
Quantity	1000kg, 40bags	MFG Date:	june 25, 2020
Contract No.		EXP date	june 24, 2022

 

ITEM		STANDARD	RESULTS
Appearance		White or almost white, amporphous or crystalline powder. Freely soluble in water and in proene glycol; very slight soluble in alcohol.	Complied
Identification	IR	Same absorption bands as USP Gamma Cyclodextrin RS	Complied
	HPLC	The retention time of the major peak of sample solution corresponds to the standard solution.	Complied
	Optical rotation	+174°--- +180°	+175°
Residue on ignition		≤0.1 %	0.1
Reducing substance		≤0.5 %	0.09
Alpha cyclodextrin		≤0.5%	Not detected
Betadex cyclodextrin		≤0.5 %	Not detected
Sum of other impurities		≤0.5 %	Not detected
Loss on drying		≤11.0 %	9.0
Color and Clarity of solution		At 420 nm, the absorbance is not greater than 0.20, and the solution	Complied
Assay		98.0%----102.0%	99.3
The total aerobic microbial count		≤1000 cfu/g	20 cfu/g
The total combined moulds and yeasts count		≤100 cfu/g	Not detected

CONCLUSION: THE QUALITY OF THIS BATCH CONFORMS OF Enterprise Standard.
INSPECTOR:Wang Hui                               QUALITY CONTROL SECTION:Long Yuan

Gamma cyclodextrin CAS No 17465-86-0
Gamma Cyclodextrin pharmaceutical grade applications:

1). In pharmaceutical field, Gamma Cyclodextrin pharmaceutical grade and medicine could produce inclusion compound,

which could: A. make unstable medicine stable; B. make deliquescing, sticky and liquid medicine

more powder-like; C. make insoluble or hard-soluble medicine soluble.

2). In pesticide field, Gamma Cyclodextrin pharmaceutical grade and medicine could produce inclusion compound

to make some pesticides store and increase insecticidal efficacy.

3). In food field,Gamma Cyclodextrin pharmaceutical grade could: A. cover and remove peculiar smell;B. improve

and enhance food organization structure; C. relieve and remove bitter and astringent;

D. anti-oxidation; E. keep and improve relish.

4). In daily chemical field, Gamma Cyclodextrin pharmaceutical grade could function as emulgator and quality improver in cosmetics production. It could also be applied in tooth paste and tooth powder

as deodorant and preservative.

5). In environment-protection field, Gamma Cyclodextrin pharmaceutical grade could be applied as treatment of waste water with oil. Alpha Cyclodextrin water solution could be used to clean oil groove

and recycle it to get fuel oil.

 

Natural Cyclodextrin;
Alpha-Cyclodextrin	Beta-Cyclodextrin		Gamma-Cyclodextrin
Alpha Cyclodextrin Derivatives;
Hydroxypropyl-Alpha-Cyclodextrin		Sulfobutylether-Alpha-Cyclodextrin
Beta Cyclodextrin Derivatives;
Hydroxypropyl-Beta-Cyclodextrin		Sulfobutyl ether-Beta-Cyclodextrin Sodium
Piroxicam-Beta-Cyclodextrin		Glucosyl-Beta-Cyclodextrin
Hydroxyethyl-Beta-Cyclodextrin		Carboxymethyl-Beta-Cyclodextrin
Hydroxypropyl-Beta-Cyclodextrin		2,6-Dimethyl-Beta-Cyclodextrin
2-Hydroxypropyl-Beta-Cyclodextrin		Methyl-Beta-Cyclodextrin
Gamma Cyclodextrin Derivatives;
Hydroxypropyl-Gamma-Cyclodextrin		Sulfobutylether-Gamma-Cyclodextrin
Cyclodextrin Inclusion Compounds
Soluble inclusion compound of pueraria flavones		Soluble inclusion compound of Gynostemma Extract
Plant essential oil inclusion compound		Flavor inclusion compound
Rotation substance separation reagent
Chromatogram filler: cyclodextrins.

 

Cyclooctapentylose Basic information

Product Name:	Cyclooctapentylose
Synonyms:	CYCLOFLO(TM) 42;CYCLOOCTAOSE;CYCLOOCTAAMYLOSE;CYCLOMALTOOCTAOSE;GAMMA-CYCLODEXTRIN;SCHARDINGER GAMMA-DEXTRIN;cyclooctapentylose;gamma-Cyclodextrin Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.0-102.0% cyclodextrin basis
CAS:	17465-86-0
MF:	C48H80O40
MW:	1297.12
EINECS:	241-482-4
Product Categories:	Alcohols;Building Blocks;C11 to C30+;C20 to C60+;Chemical Synthesis;Ethers;Organic Building Blocks;Oxygen Compounds;Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Dextrins,Sugar & Carbohydrates
Mol File:	17465-86-0.mol

Cyclooctapentylose Chemical Properties

Melting point	≥300 °C
alpha	[α]D25 +174~+179° (c=1, H2O) (After Drying)
Boiling point	845.2°C (rough estimate)
density	1.2064 (rough estimate)
refractive index	1.7500 (estimate)
Fp	450ºC
solubility	1 M NaOH: 25 mg/mL, may be clear to slightly hazy
pka	11.68±0.70(Predicted)
form	powder
color	white
optical activity	[α]/D 174.0 to 180.0°
Water Solubility	232g/L(25 ºC)
λmax	λ: 420 nm Amax: ≤0.20
Merck	14,2718
BRN	5725162
InChIKey	GDSRMADSINPKSL-HSEONFRVSA-N
EPA Substance Registry System	.gamma.-Cyclodextrin (17465-86-0)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-24/25-22
WGK Germany	2
RTECS	GU2293080
F	3
HS Code	29400000

Cyclooctapentylose Usage And Synthesis

Chemical Properties	White powder or crystal
Chemical Properties	Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.
Production Methods	Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.
Pharmaceutical Applications	Cyclodextrins are 'bucketlike' or 'conelike' toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex. Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability. Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material. γ-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules;it has low toxicity and enhanced water solubility. In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent. In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation. Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.
Safety	Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations. Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity. Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries. Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic. γ-Cyclodextrin LD50 (rat, IP): 4.6 g/kg LD50 (rat ,IV): 4.0 g/kg LD50 (rat, oral): 8.0 g/kg
storage	Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.
Regulatory Status	Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections). Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.

Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on.
Our food additives and food ingredients, especially our Ascorbic Acid (Vitamin C), Acesulfame-K, Aspartame, Citrates, Dextrose, D-Xylose, Erythorbic Acid, Fumaric Acid, Fructose,Maltodextrin, Malic Acid, Monosodium glutamate, Lactic Acid Potassium Sorbate, Sodium Erythorbate, Sodium Cyclamate, Sodium Saccharin, sodium benzoate, Sodium ascorbate, Sorbic Acid, xanthan Gum, Xylitol, Tartaric Acid, I+G, , Vanillin, Sucralose, Stevia and so on, have been exported to more than 60 countries for our good quality products.
Our staff of sales and technical support is available to help you in selecting the right protection for your application as well as to provide you with samples of our products for evaluation. At High Five, we are committed to providing the highest level of customer service, competitive pricing, speedy delivery and a comprehensive, cutting-edge product offering. Our ultimate goal is your satisfaction.





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FAQ
Q1.What's the payment terms?
We could accept T/T, L/C, DP payment terms.

Q2.How about the different index of products in same application?
Specifications can be customized according to your application.

Q3.How about the samples of products?
We can provide free samples under 2Kg(not including freight charge).

Q4.How about the price of products?
Our products are chemical synthesis got from underground brine, which is available for a variety of usage. Our products are high purity with good quality, and the price is based on different specification and quantity.

Q5.What's the shelf life for the cargoes?
Our product's shelf life is 2 years, which is based on dry and ventilated storage.

Q6.What's the package of the cargoes?
20kg/25kg woven bags, within plastic bags, or as customized.

Q7.What's the delivery time?
We usually deliver the cargoes within 10~20 days after receiving customer's payment or original L/C.

Q8.Which documents can we supply?
Commercial Invoice, Packing List, Certificate of Analysis, Certificate of Origin (FORM E), Bill of Loading, ISO etc.
The documents will be sent by Express within 24 hours against your full payment.

Q9.Why do you choose us?
We accept safe and diversified payment terms.
We supply a price trend to ensure clients know marketing information in time. We will take charge of 100% responsibility for
quality issue. We strive to create value for each customer we serve by meeting their unique needs and providing solutions to solve their problems and achieve their objectives.