18β-Glycyrrhetinic Acid (Enoxolone)
Chinese Name:18β-Glycyrrhetinic Acid (Enoxolone)
CAS:471-53-4
Application:,,.
Loss on Drying:≤1.0%
Residue on Ignition:≤0.20 %
Assay:Titr≥98%
Notes:It is used in cosmetics to improve the immune functionality of skin, strengthen disease resistance of skin, reduce inflammation, prevent allergies, clean skin and remove toxins and help reduce the side effects of cosmetics. It can also prevent the generation of melanin.
| 8β-Glycyrrhetinic Acid Basic information |
| Product Name: |
18β-Glycyrrhetinic Acid |
| Synonyms: |
18Β-GLYCYRRHETINIC ACID;3.beta.-Hydroxy-11-oxo-12-oleanen-30-oicacid;3-beta-hydroxy-11-oxo-olean-12-en-30-oicaci;3-beta-hydroxy-11-oxoolean-12-en-30-oicacid;3-hydroxy-11-oxo-,(3.beta.,20.beta.)-Olean-12-en-29-oicacid;3-hydroxy-11-oxo-,(3beta,20beta)-olean-12-en-29-oicaci;3-Hydroxy-11-oxo-12-oleanen-30-oicacid;3BETA-HYDROXY-11-OXO-18BETA, 20BETA-OLEAN-12-EN-29-OIC ACID |
| CAS: |
471-53-4 |
| MF: |
C30H46O4 |
| MW: |
470.68 |
| EINECS: |
207-444-6 |
| Product Categories: |
Pentacyclic Triterpenes;Tri-Terpenoids;Inhibitors;Cosmetic Ingredients & Chemicals;Chiral Reagents;Heterocycles;Miscellaneous;Biochemistry;Terpenes;Terpenes (Others);Natural Plant Extract;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: |
471-53-4.mol |
| |
| |
| 18β-Glycyrrhetinic Acid Chemical Properties |
| Melting point |
292-295 °C(lit.) |
| alpha |
165 º (c=1, CHCl3,on dry ba) |
| Boiling point |
492.11°C (rough estimate) |
| density |
0.9967 (rough estimate) |
| refractive index |
162 ° (C=1, MeOH) |
| solubility |
Practically insoluble in water, soluble in ethanol, sparingly soluble in methylene chloride. |
| pka |
pKa 5.56±0.1 (Uncertain) |
| form |
Crystalline Powder |
| color |
White to off-white |
| optical activity |
[α]22/D +170.0°, c = 1 in chloroform |
| Water Solubility |
SOLUBLE IN ACETIC ACID |
| Merck |
14,3590 |
| BRN |
2229654 |
| CAS DataBase Reference |
471-53-4(CAS DataBase Reference) |
| EPA Substance Registry System |
Enoxolone (471-53-4) |
| Hazard Codes |
Xn |
| Risk Statements |
22-36 |
| Safety Statements |
22-24/25 |
| WGK Germany |
3 |
| RTECS |
RK0180000 |
| HS Code |
29189900 |
| Provider |
Language |
| 18-beta-Glycyrrhetinic acid |
English |
| SigmaAldrich |
English |
| ACROS |
English |
| |
| 18β-Glycyrrhetinic Acid Usage And Synthesis |
| Chemical Properties |
white or greyish-white crystalline powder |
| Uses |
An anti-inflammatory (topical). |
| Uses |
antitussive, antiinflammatory, antibacterial |
| Uses |
The aglycone of the triterpenoid Glyccyrrhizic acid. |
| Uses |
glycyrrhetinic acid is anti-irritant, anti-allergenic, anti-inflammatory, skin-lightening, and smoothing properties are attributed to this ingredient, which is also a carrier. It is the organic compound derived from glycyrrhizic acid or shredded licorice roots. |
| Definition |
ChEBI: A pentacyclic triterpenoid that is olean-12-ene substituted by a hydroxy group at position 3, an oxo group at position 11 and a carboxy group at position 30. |
| Anticancer Research |
Glycyrrhetinic acid in combinationwith etoposide inhibits thetopoisomerase 2α and inducesapoptosis
Cai et al.(2017) |
| Anticancer Research |
It was reported that GA at noncytotoxic concentrationshowed synergistic effect in combination with anticancer drug, etoposide (VP-16).Specifically, GA enhanced cytotoxicity through regulating topoisomerase II-αtargeted by etoposide. Also, GA sensitized the cells to etoposide through elevatingtopoisomerase II-α with a 2.4-fold rate at 12 h time point. From 12 to 48 h, GAhalved the expression of topoisomerase II-α and stimulated apoptosis, whichexhibited its antineoplastic effect. They reported that GA was more potentiallyeliminating the TNBC cells when compared with Glycyrrhizin Acid (Cai et al. 2017). |
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