| BETA-CYCLODEXTRIN Basic information |
| Description References |
| Product Name: |
BETA-CYCLODEXTRIN |
| Synonyms: |
BCD;3,4-dihydroxy-6-(hydroxymethyl)-5-methyl-2-oxanolate;β-cyclodextrin crystalline;BETA BYCLODEXTRIN;SCHARDINGER BETA-DEXTRIN;Schardinger β-Dextrin ;b-Cyclodextrin (1.02127);B-cyclodextrin cell culture tested |
| CAS: |
7585-39-9 |
| MF: |
C42H70O35 |
| MW: |
1134.98 |
| EINECS: |
231-493-2 |
| Product Categories: |
Industrial/Fine Chemicals;Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Inhibitors;Sugars;Dextrins,Sugar & Carbohydrates;Cosmetic Ingredients & Chemicals |
| Mol File: |
7585-39-9.mol |
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| |
| BETA-CYCLODEXTRIN Chemical Properties |
| Melting point |
>260 °C (dec.)(lit.) |
| alpha |
[α]D25 +159~+165° (c=1, H2O) (After Drying) |
| Boiling point |
844.96°C (rough estimate) |
| density |
1.2296 (rough estimate) |
| FEMA |
4028 | BETA-CYCLODEXTRIN |
| refractive index |
1.7500 (estimate) |
| storage temp. |
+15C to +30C |
| solubility |
1 M NaOH: 50 mg/mL |
| pka |
11.73±0.70(Predicted) |
| form |
powder |
| color |
white |
| PH |
5.0-8.0 (1% in solution, Ph Eur) |
| optical activity |
[α]20/D +162±3°, c = 1.5% in H2O |
| Water Solubility |
Soluble in water and ammonium hydroxide. |
| Merck |
14,2718 |
| BRN |
78623 |
| Stability: |
Stable. Incompatible with strong oxidizing agents. |
| EPA Substance Registry System |
.beta.-Cyclodextrin (7585-39-9) |
| Hazard Codes |
Xi |
| Risk Statements |
36/37/38-20 |
| Safety Statements |
26-36-24/25 |
| WGK Germany |
2 |
| RTECS |
GU2293000 |
| TSCA |
Yes |
| HS Code |
29400000 |
The production of cyclodextrins is relatively simple and involves treatment of ordinary starch with a set of easily available enzymes. Commonly cyclodextrin glycosyltransferase (CGTase) is employed along with α -amylase. First starch is liquified either by heat treatment or using α -amylase, then CGTase is added for the enzymatic conversion. CGTases can synthesize all forms of cyclodextrins, thus the product of the conversion results in a mixture of the three main types of cyclic molecules, in ratios that are strictly dependent on the enzyme used: Each CGTase has its own characteristic α : β : γ Synthesis ratio. Purification of the three types of cyclodextrins takes advantage of the different water solubility of the molecules: β -CD which is very poorly water soluble (18.5 g/l or 16.3mM) (at 25C? ? ? ) can be easily retrieved through crystallization while the more soluble α - and γ -CDs (145 and 232 g/l respectively) are usually purified by means of expensive and time consuming chromatography techniques. As an alternative a "complexing agent" can be added during the enzymatic conversion step: Such agents (usually organic solvents like tne, tone or ethanol) form a complex with the desired cyclodextrin which subsequently precipitates. The complex formation drives the conversion of starch towards the synthesis of the precipitated cyclodextrin, thus enriching its content in the final mixture of products. The precipitated cyclodextrin is easily retrieved by centrifugation and is later separated from the complexing agent.
Uses
Crystal structure of a rotaxane with an α -cyclodextrin macrocycle. [2]
Cyclodextrins are able to form host-guest complexes with hydrophobic molecules given the unique nature imparted by their structure. As a result these molecules have found a number of applications in a wide range of fields. Other than the above mentioned pharmaceutical applications for drug release, cyclodextrins can be employed in environmental protection: These molecules can effectively immobilise inside their rings toxic compounds, like trichloroethane or heavy metals, or can form complexes with stable substances, like trichlorfon (an organophosphorus insecticide) or sewage sludge, enhancing their decomposition.
In the food industry cyclodextrins are employed for the preparation of cholesterol free products: The bulky and hydrophobic cholesterol molecule is easily lodged inside cyclodextrin rings that are then removed. Other food applications further include the ability to stabilize volatile or unstable compounds and the reduction of unwanted tastes and odour. Reportedly cyclodextrins are used in alcohol powder, a powder for mixing alcoholic drinks.
The strong ability of complexing fragrances can also be used for another purpose: First dry, solid cyclodextrin microparticles are exposed to a controlled contact with fumes of active compounds, then they are added to fabric or paper products. Such devices are capable of releasing fragrances during ironing or when heated by human body. Such a device commonly used is a typical 'dryer sheet'. The heat from a clothes dryer releases the fragrance into the clothing.
The ability of cyclodextrins to form complexes with hydrophobic molecules has LED to their usage in supramolecular chemistry. In particular they have been used to synthesize certain mechanically-interlocked molecular architectures, such as rotaxanes and catenanes, by reacting the ends of the threaded guest.
The application of cyclodextrin as supramolecular carrier are also possible in organometallic reaction. The mechanism of action probably take place in the interfacial region (see L. Leclercq et al. ). Wipff are also demonstrated by computational study that the reaction occur in the interfacial layer. The application of cyclodextrins as supramolecular carrier is possible in various organomettalic catalysis.
| Natural Cyclodextrin; |
| Alpha-Cyclodextrin |
Beta-Cyclodextrin |
Gamma-Cyclodextrin |
| Alpha Cyclodextrin Derivatives; |
| Hydroxypropyl-Alpha-Cyclodextrin |
Sulfobutylether-Alpha-Cyclodextrin |
| Beta Cyclodextrin Derivatives; |
|
| Hydroxypropyl-Beta-Cyclodextrin |
Sulfobutyl ether-Beta-Cyclodextrin Sodium |
| Piroxicam-Beta-Cyclodextrin |
Glucosyl-Beta-Cyclodextrin |
| Hydroxyethyl-Beta-Cyclodextrin |
Carboxymethyl-Beta-Cyclodextrin |
| Hydroxypropyl-Beta-Cyclodextrin |
2,6-Dimethyl-Beta-Cyclodextrin |
| 2-Hydroxypropyl-Beta-Cyclodextrin |
Methyl-Beta-Cyclodextrin |
| Gamma Cyclodextrin Derivatives; |
| Hydroxypropyl-Gamma-Cyclodextrin |
Sulfobutylether-Gamma-Cyclodextrin |
| Cyclodextrin Inclusion Compounds |
| Soluble inclusion compound of pueraria flavones |
Soluble inclusion compound of Gynostemma Extract |
| Plant essential oil inclusion compound |
Flavor inclusion compound |
| Rotation substance separation reagent |
| Chromatogram filler: cyclodextrins. |
Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on.
Our food additives and food ingredients, especially our Ascorbic Acid (Vitamin C), Acesulfame-K, Aspartame, Citrates, Dextrose, D-Xylose, Erythorbic Acid, Fumaric Acid, Fructose,Maltodextrin, Malic Acid, Monosodium glutamate, Lactic Acid Potassium Sorbate, Sodium Erythorbate, Sodium Cyclamate, Sodium Saccharin, sodium benzoate, Sodium ascorbate, Sorbic Acid, xanthan Gum, Xylitol, Tartaric Acid, I+G, , Vanillin, Sucralose, Stevia and so on, have been exported to more than 60 countries for our good quality products.
Our staff of sales and technical support is available to help you in selecting the right protection for your application as well as to provide you with samples of our products for evaluation. At High Five, we are committed to providing the highest level of customer service, competitive pricing, speedy delivery and a comprehensive, cutting-edge product offering. Our ultimate goal is your satisfaction.
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We could accept T/T, L/C, DP payment terms.
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Specifications can be customized according to your application.
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We can provide free samples under 2Kg(not including freight charge).
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Our products are chemical synthesis got from underground brine, which is available for a variety of usage. Our products are high purity with good quality, and the price is based on different specification and quantity.
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Our product's shelf life is 2 years, which is based on dry and ventilated storage.
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We usually deliver the cargoes within 10~20 days after receiving customer's payment or original L/C.
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