Ascorbic Acid CAS. No. 50-81-7 Vitamin C E300

• Customization: Available
• CAS No.: 50-81-7
• Formula: C6h8o6
• Model NO.: food grade
• EINECS: 200-066-2
• Packaging Material: Paper
• Storage Method: Normal
• Shelf Life: 36month
• Type: Food Ingredint
• Resource: Chemosynthesis
• Store: Kept in a Light-Proof, Well-Closed, Dry and Cool P
• Molecular Weight: 176.13
• En. No.: E300
• Delivry: 15days
• Loading: Qingdao
• Loading Port: Shanghai
• Transport Package: 25kg/Caron
• Specification: BP/USP/FCC
• Trademark: JK
• Origin: China
• HS Code: 293627
• Production Capacity: 1000mt/Month

Product Description

Ascorbic acid is a naturally occurring organic compound with antioxidant properties. It is a white solid, but impure samples can appear yellowish. It dissolves well in water to give mildly acidic solutions. Because it is derived from glucose, many animals are able to produce it, but humans require it as part of their nutrition. Other vertebrates which lack the ability to produce ascorbic acid include other primates, guinea pigs, teleost fishes, bats, and some birds, all of which require it as a dietary micronutrient (that is, in vitamin form).

There exists a D-ascorbic acid, which does not occur in nature. It may be synthesized artificially. It has identical antioxidant properties to L-ascorbic acid yet has far less vitamin C activity (although not quite zero).

[Characteristics ] colorless crystals or a white or almost white, crystalline powder which discolors on exposure to air and moisture; Odorless or almost odorless and tasted sour; Easily soluble in water and a few partial soluble in ethanol; Insoluble in ether and chloroform.

[Product specification ] BP/USP/EP/JP/FCC

[Function]It applies mainly to production of various medicines as clinically important material for supplementary cure practice in different sectors. Being food additives, it acts as superior and reliable agent in nutrition, antiseptic and flour processing aspects. It also helps enhance the immune system of animals as being served in feed additives.

[Package]25kg net weight carton box or drum with two plastic inner linings and vacuum-sealed bag.

[Storage ]shielded from light, dry and cool placement, sealed for storage.
 

 Vitamin C 40-80-100Mesh

 Vitamin C Powder

 Vitamin C Granule

 Medical Grade Vitamin C

 Food Grade Vitamin C

 

Item		Specification --BP 2000 / USP 32 / FCC IV
Name		Vitamin C
Appearance		White or almost white granule or granular powder
Assay		99.0 -105.0%
Identificatrion		Positive
Clearity and color of solution		Clear , <BY7
specific oprical rotation		+20.5°~+21.5°+21.0°
Inactive Ingredients		Ethyl Cellulose
CAS No.		50-81-7
Fomula		C6H8O6
Melting Point		190°C
Loss on drying		0.25%
PH5%,W/V		2.1~2.62.3
Residue on  ignition		<0.1%
Heavy metal		<10ppm
Arsenic		<3ppm
Mehs size distribution		> 20 mesh < 5%  > 40 mesh 20%  > 60 mesh 60%  > 80 mesh 10%  >100 mesh 5%
Identification		Positive reaction
Functional use		Nutritional Enhancer
Packing		25kg/carton

 

L(+)-Ascorbic acid Basic information

Product Name:	L(+)-Ascorbic acid
Synonyms:	L-Ascorbic acid, 99.99% metals basis;Ascorbic aci;L-ASCORBIC ACID, REAGENT (ACS)L-ASCORBIC ACID, REAGENT (ACS)L-ASCORBIC ACID, REAGENT (ACS)L-ASCORBIC ACID, REAGENT (ACS);Ascorbic aicd;Nano Liposomal VC;Vitamin C (Ascorbic Acid) Liposome, Oil-Soluble Vitamin C;L-(+)-ASCORBIC ACID PWD;Ascorbic acid Manufacturer
CAS:	50-81-7
MF:	C6H8O6
MW:	176.12
EINECS:	200-066-2
Product Categories:	Antioxidant;Biochemistry;Sugar Acids;Sugars;Vitamins;Nutritional Supplements;PHARMACEUTICALS;Food and Feed Additive;Acid;Vitamins and Derivatives;Carbohydrates & Derivatives;Vitamin Ingredients;Food Additives,Medicine;Inhibitors;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Used in medicine and Food Additives;vitamin
Mol File:	50-81-7.mol

L(+)-Ascorbic acid Chemical Properties

Melting point	190-194 °C (dec.)
alpha	20.5 º (c=10,H2O)
Boiling point	227.71°C (rough estimate)
density	1,65 g/cm^3
FEMA	2109 | ASCORBIC ACID
refractive index	21 ° (C=10, H2O)
storage temp.	0-6°C
solubility	H2O: 50 mg/mL at 20 °C, clear, nearly colorless
form	powder
pka	4.04, 11.7(at 25ºC)
color	white to slightly yellow
PH	1.0 - 2.5 (25ºC, 176g/L in water)
PH Range	1 - 2.5
Odor	Odorless
optical activity	[α]25/D 19.0 to 23.0°, c = 10% in H2O
Water Solubility	333 g/L (20 ºC)
Merck	14,830
BRN	84272
Stability:	Stable. May be weakly light or air sensitive. Incompatible with oxidizing agents, alkalies, iron, copper.
InChIKey	CIWBSHSKHKDKBQ-JLAZNSOCSA-N
CAS DataBase Reference	50-81-7(CAS DataBase Reference)
NIST Chemistry Reference	L-Ascorbic acid(50-81-7)
EPA Substance Registry System	Ascorbic acid (50-81-7)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	24/25-36-26
RIDADR	UN 1648 3 / PGII
WGK Germany	1
RTECS	CI7650000
TSCA	Yes
HS Code	29362700
Hazardous Substances Data	50-81-7(Hazardous Substances Data)
Toxicity	LD50 oral in rat: 11900mg/kg

MSDS Information

Provider	Language
L-Threo-2,3,4,5,6-pentahydroxy-1-hexenoic acid-4-lactone	English
SigmaAldrich	English
ACROS	English
ALFA	English

L(+)-Ascorbic acid Usage And Synthesis

Description	Ascorbic acid, a water-soluble dietary supplement, is consumed by humans more than any other supplement. The name ascorbic means antiscurvy and denotes the ability of ascorbic to combat this disease. Vitamin C is the l-enantiomer of ascorbic acid. Ascorbic acid deficiency in humans results in the body's inability to synthesize collagen, which is the most abundant protein in vertebrates.
Chemical Properties	White crystals (plates or needles). Soluble in water; slightly soluble in alcohol; insoluble in ether, chloroform, benzene, petroleum ether, oils and fats. Stable to air when dry. One international unit is equivalent to 0.05 milligram of l-ascorbic acid.
Chemical Properties	Ascorbic acid occurs as a white to light-yellow-colored, nonhygroscopic, odorless, crystalline powder or colorless crystals with a sharp, acidic taste. It gradually darkens in color upon exposure to light.
Uses	vitamin C is a well-known anti-oxidant. Its effect on free-radical formation when topically applied to the skin by means of a cream has not been clearly established. The effectiveness of topical applications has been questioned due to vitamin C's instability (it reacts with water and degrades). Some forms are said to have better stability in water systems. Synthetic analogues such as magnesium ascorbyl phosphate are among those considered more effective, as they tend to be more stable. When evaluating its ability to fight free-radical damage in light of its synergistic effect with vitamin e, vitamin C shines. As vitamin e reacts with a free radical, it, in turn, is damaged by the free radical it is fighting. Vitamin C comes in to repair the free-radical damage in vitamin e, allowing e to continue with its free-radical scavenging duties. Past research has indicated that high concentrations of topically applied vitamin C are photoprotective, and apparently the vitamin preparation used in these studies resisted soap and water, washing, or rubbing for three days. More current research has indicated that vitamin C does add protection against uVB damage when combined with uVB sunscreen chemicals. This would lead one to conclude that in combination with conventional sunscreen agents, vitamin C may allow for longer-lasting, broader sun protection. Again, the synergy between vitamins C and e can yield even better results, as apparently a combination of both provides very good protection from uVB damage. However, vitamin C appears to be significantly better than e at protecting against uVA damage. A further conclusion is that the combination of vitamins C, e, and sunscreen offers greater protection than the sum of the protection offered by any of the three ingredients acting alone. Vitamin C also acts as a collagen biosynthesis regulator. It is known to control intercellular colloidal substances such as collagen, and when formulated into the proper vehicles, can have a skin-lightening effect. Vitamin C is said to be able to help the body fortify against infectious conditions by strengthening the immune system. There is some evidence (although debated) that vitamin C can pass through the layers of the skin and promote healing in tissue damaged by burns or injury. It is found, therefore, in burn ointments and creams used for abrasions. Vitamin C is also popular in anti-aging products. Current studies indicate possible anti-inflammatory properties as well.
Uses	antiscorbutic, antiviral
Uses	analgesic, antipyretic
Uses	Physiological antioxidant. Coenzyme for a number of hydroxylation reactions; required for collagen synthesis. Widely distributed in plants and animals. Inadequate intake results in deficiency syndrome s such as scurvy. Used as antimicrobial and antioxidant in foodstuffs.
Uses	Sodium, potassium, and calcium salts of ascorbic acids are called ascorbates and are used as food preservatives. To make ascorbic acid fat-soluble, it can be esterified. Esters of ascorbic acid and acids, such as palmitic acid to form ascorbyl palmitate and stearic acid to form ascorbic stearate, are used as antioxidants in food, pharmaceuticals, and cosmetics. Ascorbic acid is also essential in the metabolism of some amino acids. It helps protect cells from free radical damage, helps iron absorption, and is essential for many metabolic processes.
Uses	The starting point for synthesis of vitamin C is the selective of oxidation of the sugar compound D-sorbit to L-sorbose using Acetobacter suboxidans bacteria. L-sorbose is then converted to L-ascorbic acid, better known as vitamin C.
Production Methods	Ascorbic acid is produced synthetically using the Reichstein process, which has been the standard method of production since the 1930s. The process starts with fermentation followed by chemical synthesis. The first step involves reduction of D-glucose at high temperature into D-sorbitol. D-sorbitol undergoes bacterial fermentation, converting it into L-sorbose. L-sorbose is then reacted with acetone in the presence of concentrated sulfuric acid to produce diacetone-L-sorbose, which is then oxidized with chlorine and sodium hydroxide to produce di-acetone-ketogulonic acid (DAKS). DAKS is then esterified with an acid catalyst and organics to give a gulonic acid methylester. The latter is heated and reacted with alcohol to produce crude ascorbic acid, which is then recrystallized to increase its purity. Since the development of the Reichstein process more than 70 years ago, it has undergone many modifications. In the 1960s, a method developed in China referred to as the two-stage fermentation process used a second fermentation stage of L-sorbose to produce a different intermediate than DAKS called KGA (2-keto-L-gulonic acid), which was then converted into ascorbic acid. The two stage process relies less on hazardous chemicals and requires less energy to convert glucose to ascorbic acid.
Indications	Vitamin C (ascorbic acid) is essential for the maintenance of the ground substance that binds cells together and for the formation and maintenance of collagen.The exact biochemical role it plays in these functions is not known, but it may be related to its ability to act as an oxidation-reduction system.
Definition	ChEBI: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Production Methods	Ascorbic acid is prepared synthetically or extracted from various vegetable sources in which it occurs naturally, such as rose hips, blackcurrants, the juice of citrus fruits, and the ripe fruit of Capsicum annuum L. A common synthetic procedure involves the hydrogenation of D-glucose to D-sorbitol, followed by oxidation using Acetobacter suboxydans to form L-sorbose. A carboxyl group is then added at C1 by air oxidation of the diacetone derivative of Lsorbose and the resulting diacetone-2-keto-L-gulonic acid is converted to L-ascorbic acid by heating with hydrochloric acid.
Brand name	Ascorbin (Marion Merrell Dow).
General Description	White to very pale yellow crystalline powder with a pleasant sharp acidic taste. Almost odorless.
General Description	Scurvy (from the French word scorbutus) has been recognized as a disease afflicting mankind for thousands of years. Citrus fruits such as oranges, lemons, and limes were later identified as equally effective treatments. Only within the last 100 years has a deficiency in vitamin C been definitively identified as the cause of scurvy. In 1932, Waugh and King isolated crystalline vitamin C from lemon juice and showed it to be the antiscorbutic factor present in each of these treatments.  The structure and chemical formula of vitamin C was identified in 1933 by Hirst et al.Because humans are one of the few animal species that cannot synthesize vitamin C, it has to be available as a dietary component. Dietary sources of ascorbic acid include fruits (especially citrus fruits), vegetables (especially peppers), and potatoes. Although the sources of some commercial products are rose hips and citrus fruits, most ascorbic acid is prepared synthetically. Vitamin C is now commonly referred to as ascorbic acid because of its acidic character and its effectiveness in the treatment and prevention of scorbutus (scurvy). The acidic character is because of the two enolic hydroxyls; the C^3 hydroxyl has a pKa value of 4.1, and the C^2 hydroxyl has a pKa of 11.6. All biological activities reside in L-ascorbic acid; therefore, all references to vitamin C, ascorbic acid, ascorbate, and their derivatives refer to this form. The monobasic sodium salt is the usual salt form.
Air & Water Reactions	May be sensitive to prolonged exposure to air and light. Sensitive to moisture. Soluble in water. Aqueous solutions are oxidized by air in a reaction that is accelerated by alkalis, iron and copper. The rate depends on the pH and on oxygen concentration. Also subject to degradation under anaerobic conditions.
Reactivity Profile	L(+)-Ascorbic acid is a lactone. Reacts as a relatively strong reducing agent and decolorizes many dyes. Forms stable metal salts. Incompatible with oxidizers, dyes, alkalis, iron and copper. Also incompatible with ferric salts and salts of heavy metals, particularly copper, zinc and manganese .
Fire Hazard	Flash point data for L(+)-Ascorbic acid are not available; however, L(+)-Ascorbic acid is probably combustible.
Pharmaceutical Applications	Ascorbic acid is used as an antioxidant in aqueous pharmaceutical formulations at a concentration of 0.01-0.1% w/v. Ascorbic acid has been used to adjust the pH of solutions for injection, and as an adjunct for oral liquids. It is also widely used in foods as an antioxidant. Ascorbic acid has also proven useful as a stabilizing agent in mixed micelles containing .
Clinical Use	Vitamin C is indicated for the treatment and prevention of known or suspect deficiency. Although scurvy occurs infrequently, it is seen in the elderly, infants, alcoholics, and drug users.Ascorbate can also be used to enhance absorption of dietary nonheme iron or iron supplements. Ascorbic acid (but not the sodium salt) was historically used to acidify the urine as a result of excretion of unchanged ascorbic acid, although this use has fallen into disfavor. Ascorbate also increases iron chelation by deferoxamine, explaining its use in the treatment of iron toxicity.
Clinical Use	Vitamin C is found in fresh fruit and vegetables. It is very water soluble, is readily destroyed by heat, especially in an alkaline medium, and is rapidly oxidized in air. Fruit and vegetables that have been stored in air, cut or bruised, washed, or cooked may have lost much of their vitamin C content. The deficiency disease associated with a lack of ascorbic acid is called scurvy. Early symptoms include malaise and follicular hyperkeratosis. Capillary fragility results in hemorrhages, particularly of the gums. Abnormal bone and tooth development can occur in growing children.The body's requirement for vitamin C increases during periods of stress, such as pregnancy and lactation.
Side effects	Megavitamin intake of vitamin C may result in diarrhea due to intestinal irritation. Since ascorbic acid is partially metabolized and excreted as oxalate, renal oxalate stones may form in some patients.
Toxicology	L-Ascorbic acid, or vitamin C, is widely present in plants. The structures of ascorbic acid and dehydroascorbic acid are shown in Figure 10.5. Vitamin C is not only an important nutrient but is also used as an antioxidant in various foods. However, it is not soluble in fat and is unstable under basic conditions. Vitamin C reduces cadmium toxicity and excess doses prolong the retention time of an organic mercury compound in a biological system. Overdoses of vitamin C (106 g) induce perspiration, nervous tension, and lowered pulse rate. WHO recommends that daily intake be less than 0.15 mg/kg. Toxicity due to ascorbic acid has not been reported. Although repeated intravenous injections of 80 mg dehydroascorbic acid was reported to be diabetogenic in rats, oral consumption of 1.5 g/day of ascorbic acid for six weeks had no effect on glucose tolerance or glycosuria in 12 normal adult males and produced no change in blood glucose concentrations in 80 diabetics after five days. The same report noted that a 100-mg intravenous dose of dehydroascorbic acid given daily for prolonged periods produced no signs of diabetes. Ascorbic acid is readily oxidized to dehydroascorbic acid, which is reduced by glutathione in blood.
Safety Profile	Moderately toxic by ingestion and intravenous routes. Human systemic effects by intravenous route: blood, changes in tubules (including acute renal failure, acute tubular necrosis). An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety	Ascorbic acid is an essential part of the human diet, with 40 mg being the recommended daily dose in the UK and 60 mg in the USA. However, these figures are controversial, with some advocating doses of 150 or 250mg daily. Megadoses of 10 g daily have also been suggested to prevent illness although such large doses are now generally considered to be potentially harmful. The body can absorb about 500 mg of ascorbic acid daily with any excess immediately excreted by the kidneys. Large doses may cause diarrhea or other gastrointestinal disturbances. Damage to the teeth has also been reported. However, no adverse effects have been reported at the levels employed as an antioxidant in foods, beverages, and pharmaceuticals. The WHO has set an acceptable daily intake of ascorbic acid, potassium ascorbate, and sodium ascorbate, as antioxidants in food, at up to 15 mg/kg bodyweight in addition to that naturally present in food. LD50 (mouse, IV): 0.52 g/kg LD50 (mouse, oral): 3.37 g/kg LD50 (rat, oral): 11.9 g/kg
storage	In powder form, ascorbic acid is relatively stable in air. In the absence of oxygen and other oxidizing agents it is also heat stable. Ascorbic acid is unstable in solution, especially alkaline solution, readily undergoing oxidation on exposure to the air.The oxidation process is accelerated by light and heat and is catalyzed by traces of copper and iron. Ascorbic acid solutions exhibit maximum stability at about pH 5.4. Solutions may be sterilized by filtration. The bulk material should be stored in a well-closed nonmetallic container, protected from light, in a cool, dry place.
Purification Methods	Crystallise it from MeOH/Et2O/pet ether [Herbert et al. J Chem Soc 1270 1933]. [Beilstein 18/5 V 26.]
Incompatibilities	Incompatible with alkalis, heavy metal ions, especially copper and iron, oxidizing materials, methenamine, phenylephrine hydrochloride, pyrilamine maleate, salicylamide, sodium nitrite, sodium salicylate, theobromine salicylate, and picotamide. Additionally, ascorbic acid has been found to interfere with certain colorimetric assays by reducing the intensity of the color produced.
Regulatory Status	GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations, injections, oral capsules, suspensions, tablets, topical preparations, and suppositories). Included in medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on.
Our food additives and food ingredients, especially our Ascorbic Acid (Vitamin C), Acesulfame-K, Aspartame, Citrates, Dextrose, D-Xylose, Erythorbic Acid, Fumaric Acid, Fructose,Maltodextrin, Malic Acid, Monosodium glutamate, Lactic Acid Potassium Sorbate, Sodium Erythorbate, Sodium Cyclamate, Sodium Saccharin, sodium benzoate, Sodium ascorbate, Sorbic Acid, xanthan Gum, Xylitol, Tartaric Acid, I+G, , Vanillin, Sucralose, Stevia and so on, have been exported to more than 60 countries for our good quality products.
Our staff of sales and technical support is available to help you in selecting the right protection for your application as well as to provide you with samples of our products for evaluation. At High Five, we are committed to providing the highest level of customer service, competitive pricing, speedy delivery and a comprehensive, cutting-edge product offering. Our ultimate goal is your satisfaction.





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