Product Description
High Purity Healthy Food Additives Raw Material Sweeteners Lactose
Quick details
Product Name: Lactose
Synonyms: MILK SUGAR MONOHYDRATE;MILK SUGAR;BETA-D-GAL-(1->4)-D-GLC MONOHYDRATE;LACTOBIOSE MONOHYDRATE;LACTOSUM MONOHYDRICUM;LACTOSE STANDARD;LACTOSE, MONOHYDRATE;L-CYSTEINE HYDROCHLORIDE;
| CAS No.: |
10039-26-6 |
| EINECS No.: |
200-559-2 |
| Molecular Formula: |
C12H24O12 |
Molecular Weight: 360.31
Melting point: ~215 °C (dec.)
Appearance: white crystal or crystalline powder
Standard: Enterprise Standard
Packing: 25KG/Drum or as per your requirements
Description:
Pharmaceutical grade lactose is produced by concentrating whey or permeate (a co-product of whey protein concentrate production) to over saturate the lactose, then removing, refining, drying and milling the lactose crystals. Pharmaceutical grade lactose is produced to meet rigid specifications, such as specific form and size distribution-monohydrate, crystalline, 40 mesh to 325 mesh, and a spray-dried mixture of crystalline and amorphous lactose for all applications. All products meet the requirements of the U.S., European and Japanese Pharmacopeia.
Application
1The product can be used as tablets and capsules of the filler or diluent
2 It also used for freeze-dried products and baby food formulations.
3 Lactose is also used in powder inhalation of diluent;
4a powdered food coloring adsorption dispersion, reduce pigment concentration, ease of use and reduces discoloration during storage
5easy to use compression molding and low water absorption characteristics, such as tablet excipients
6 the use of lactose caramel lower temperature (sucrose 163 ° C, glucose-154.5 ° 7only lactose 129.5 ° C) characteristics of some special baked goods, darker at lower baking temperature yellow to caramel color.
8 the other to prevent crystallization, reduce sweetness, flavor, etc. To prevent adhesion and enhanced role.
9 for baby food, candy and margarine
| Lactose Basic information |
| Product Name: |
Lactose |
| Synonyms: |
LACTIN;LACTOSE;D-(+)-LACTOSE;D-LACTOSE;BETA-LACTOSE;4-(B-D-GALACTOSIDO)-D-GLUCOSE;4-O-BETA-GALACTOPYRANOSYL-D-GLUCOSE;SUGAR MILK |
| CAS: |
63-42-3 |
| MF: |
C12H22O11 |
| MW: |
342.3 |
| EINECS: |
200-559-2 |
| Product Categories: |
Dextrins,Sugar & Carbohydrates;medicine excipents;Inhibitors;Imidazoles |
| Mol File: |
63-42-3.mol |
| |
| |
| Lactose Chemical Properties |
| Melting point |
222.8°C |
| Boiling point |
397.76°C (rough estimate) |
| density |
1.5300 |
| refractive index |
1.5376 (estimate) |
| solubility |
Freely but slowly soluble in water, practically insoluble in ethanol (96 per cent). |
| pka |
12.39±0.20(Predicted) |
| form |
Powder |
| color |
White to Off-white |
| Water Solubility |
5-10 g/100 mL at 20 ºC |
| BRN |
93796 |
| Stability: |
Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference |
63-42-3(CAS DataBase Reference) |
| NIST Chemistry Reference |
D-Glucose, 4-o-«beta»-D-galactopyranosyl-(63-42-3) |
| EPA Substance Registry System |
Lactose (63-42-3) |
| Safety Statements |
24/25 |
| WGK Germany |
2 |
| RTECS |
OD9625000 |
| TSCA |
Yes |
| HS Code |
17021100 |
| Provider |
Language |
| 4-(beta-D-Galactosido)-D-glucose |
English |
| SigmaAldrich |
English |
| |
| Lactose Usage And Synthesis |
| Chemical Properties |
white crystals or powder |
| Chemical Properties |
Anhydrous lactose occurs as white to off-white crystalline particles or powder. Several different brands of anhydrous lactose are commercially available which contain anhydrous b-lactose and anhydrous a-lactose. Anhydrous lactose typically contains 70-80% anhydrous b-lactose and 20-30% anhydrous a-lactose. |
| Uses |
A disaccharide sugar present in milk. |
| Uses |
Lactose is a disaccharide carbohydrate that occurs in mammalian milk except that of the whale and the hippopotamus. it is princi- pally obtained as a cows' milk derivative. it is also termed milk sugar and it is a reducing sugar consisting of glucose and galactose. its most common commercial form is alpha-monohydrate, with the beta-anhydride form available to a lesser extent. all forms in solution will equilibrate to a beta:alpha ratio of 62.25:37.75 at 0°c. it is about one-sixth as sweet as sugar and is less soluble. it functions as a flow agent, humectant, crystallization control agent, and sweetener. it is used in baked goods for flavor, browning, and tenderizing and in dry mixes as an anticaking agent. |
| Production Methods |
There are two anhydrous forms of lactose: a-lactose and b-lactose. The temperature of crystallization influences the ratio of a- and blactose. The anhydrous forms that are commercially available may exhibit hygroscopicity at high relative humidities. Anhydrous lactose is produced by roller drying a solution of lactose above 93.5°C. The resulting product is then milled and sieved. Two anhydrous a-lactoses can be prepared using special drying techniques: one is unstable and hygroscopic; the other exhibits good compaction properties. However, these materials are not commercially available. |
| Definition |
A sugar found in milk. It is a disaccharide composed of glucose and galactose units. |
| Air & Water Reactions |
Water soluble. |
| Reactivity Profile |
Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. |
| Health Hazard |
ACUTE/CHRONIC HAZARDS: Lactose should be considered toxic. |
| Pharmaceutical Applications |
Anhydrous lactose is widely used in direct compression tableting applications, and as a tablet and capsule filler and binder. Anhydrous lactose can be used with moisture-sensitive drugs due to its low moisture content. It may also be used in intravenous injections. |
| Safety |
Lactose is widely used in pharmaceutical formulations as a diluent and filler-binder in oral capsule and tablet formulations. It may also be used in intravenous injections. Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the intestinal enzyme lactase, and is associated with oral ingestion of amounts well over those found in solid dosage forms. |
| storage |
Mold growth may occur under humid conditions (80% RH and above). Lactose may develop a brown coloration on storage, the reaction being accelerated by warm, damp conditions. At 80°C and 80% RH, tablets containing anhydrous lactose have been shown to expand 1.2 times after one day.
Lactose anhydrous should be stored in a well-closed container in a cool, dry place. |
| Purification Methods |
-Lactose crystallises from water below 93.5o as the hydrate which can be dried at 80o/14mm. [Horst Recl Trav Chim, Pays-Bas 72 878 1953, Beilst 17 III/IV 3066.] |
| Incompatibilities |
Lactose anhydrous is incompatible with strong oxidizers. When mixtures containing a hydrophobic leukotriene antagonist and anhydrous lactose or lactose monohydrate were stored for six weeks at 40°C and 75% RH, the mixture containing anhydrous lactose showed greater moisture uptake and drug degradation.
Studies have also shown that in blends of roxifiban acetate (DMP-754) and lactose anhydrous, the presence of lactose anhydrous accelerated the hydrolysis of the ester and amidine groups.
Lactose anhydrous is a reducing sugar with the potential to interact with primary and secondary amines (Maillard reaction) when stored under conditions of high humidity for extended periods. |
| Regulatory Status |
GRAS listed. Included in the FDA Inactive Ingredients Database (IM, IV: powder for injection solution; IV and sublingual preparations; oral: capsules and tablets; powder for inhalation; vaginal). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. |
Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on.
Our food additives and food ingredients, especially our Ascorbic Acid (Vitamin C), Acesulfame-K, Aspartame, Citrates, Dextrose, D-Xylose, Erythorbic Acid, Fumaric Acid, Fructose,Maltodextrin, Malic Acid, Monosodium glutamate, Lactic Acid Potassium Sorbate, Sodium Erythorbate, Sodium Cyclamate, Sodium Saccharin, sodium benzoate, Sodium ascorbate, Sorbic Acid, xanthan Gum, Xylitol, Tartaric Acid, I+G, , Vanillin, Sucralose, Stevia and so on, have been exported to more than 60 countries for our good quality products.
Our staff of sales and technical support is available to help you in selecting the right protection for your application as well as to provide you with samples of our products for evaluation. At High Five, we are committed to providing the highest level of customer service, competitive pricing, speedy delivery and a comprehensive, cutting-edge product offering. Our ultimate goal is your satisfaction.
Packing&Shipping
FAQ
Q1.What's the payment terms?
We could accept T/T, L/C, DP payment terms.
Q2.How about the different index of products in same application?
Specifications can be customized according to your application.
Q3.How about the samples of products?
We can provide free samples under 2Kg(not including freight charge).
Q4.How about the price of products?
Our products are chemical synthesis got from underground brine, which is available for a variety of usage. Our products are high purity with good quality, and the price is based on different specification and quantity.
Q5.What's the shelf life for the cargoes?
Our product's shelf life is 2 years, which is based on dry and ventilated storage.
Q6.What's the package of the cargoes?
20kg/25kg woven bags, within plastic bags, or as customized.
Q7.What's the delivery time?
We usually deliver the cargoes within 10~20 days after receiving customer's payment or original L/C.
Q8.Which documents can we supply?
Commercial Invoice, Packing List, Certificate of Analysis, Certificate of Origin (FORM E), Bill of Loading, ISO etc.
The documents will be sent by Express within 24 hours against your full payment.
Q9.Why do you choose us?
We accept safe and diversified payment terms.
We supply a price trend to ensure clients know marketing information in time. We will take charge of 100% responsibility for
quality issue. We strive to create value for each customer we serve by meeting their unique needs and providing solutions to solve their problems and achieve their objectives.
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