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| Powder: | Yes |
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Synonyms: 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate;[2r-[2r*(4r*,8r*)]]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-ol acetate;ALPHA-TOCOPHERYL ACETATE;ALPHA-TOCOPHERYLIS ACETAS;(+/-)-ALPHA-TOCOPHEROL ACETATE;
CAS NO.: 7695-91-2
Molecular formula: C31H52O3
Molecular weight: 472.74
EINECS: 231-710-0
Appearance: white powder
Melting point: -28°C
Boiling point: 224 °C0.3 mm Hg(lit.)
Storage: 2-8°C
Description:
Tocopheryl acetate, also known as vitamin E acetate, is a common vitamin supplement.
It is the ester of acetic acid and tocopherol (vitamin E). It is often used in dermatological products such as skin creams. Tocopheryl acetate is not oxidized and can penetrate through the skin to the living cells, where about 5% is converted to free tocopherol and provides beneficial antioxidant effects.
COA
Tocopheryl Acetate Specification :
| Item | Spec. | Result |
| Assay (on dried basis ) | 98%~102.0% | 98.70% |
| Water | ≤1.0% | 0..34% |
| Specific optical rotation | +29.0°~ +31.5° | 30.07° |
| Limit of aminopropanol | ≤1.0% | 0.17% |
| Residue on ignition | ≤0.1% | 0.06% |
| Refractive index(20°) | 1.495~1.520 | Conforms |
| Heavy metals | ≤20ppm | Conforms |
| Organic volatile impurities | Meets the requirements | Conforms |
Tocopheryl Acetate Function :
Research on the effects of D Alpha Tocopheryl Acetate on heart disease is often contradictory and inconclusive. The Linus Pauling Institute states that at least five studies have found that D Alpha Tocopheryl Acetate decreases the risk of heart attack and death from heart disease, but according to the Office of Dietary Supplements, the most stringently conducted research has not found any benefit from D Alpha Tocopheryl Acetate in preventing heart or managing heart disease, and the nutrient does not appear to decrease the risk of death from heart disease either. It is not known whether younger people derive any heart protective benefits from D alpha Tocopherol.
Tocopheryl Acetate Application:
As an antioxidant, vitamin E acts as a peroxyl radical scavenger, preventing the propagation of free radicals in tissues, by reacting with them to form a tocopheryl radical, which will then be reduced by a hydrogen donor (such as vitamin C) and thus return to its reduced state.
· As an enzymatic activity regulator, for instance, protein kinase C (PKC), which plays a role in smooth, can be inhibited by α-tocopherol.
· Vitamin E also has an effect on gene expression. Macrophages rich in cholesterol are found in the atherogenetic tissue.
· Vitamin E also plays a role in neurological functions,and inhibition of platelet aggregation
· Vitamin E also protects lipids and prevents the oxidation of polyunsaturated fatty acids.
| Tocopheryl acetate Basic information |
| Product Name: | Tocopheryl acetate |
| Synonyms: | DL-TOCOPHRIN;DL-VITAMIN E ACETATE;DL-CONTOPHERON;DL-ECON;DL-FERTILVIT;DL-ALPHA-TOCOPHEROL ACETATE;DL-ALPHA-TOCOPHERYL ACETATE;DL-ALFACOL |
| CAS: | 7695-91-2 |
| MF: | C31H52O3 |
| MW: | 472.74 |
| EINECS: | 231-710-0 |
| Product Categories: | Antioxidant;Biochemistry;Organics;Vitamin series;Vitamins;Vitamins and derivatives;food additives |
| Mol File: | 7695-91-2.mol |
| Tocopheryl acetate Chemical Properties |
| Melting point | -28°C |
| Boiling point | 224 °C0.3 mm Hg(lit.) |
| density | 0.96 g/mL at 20 °C(lit.) |
| vapor density | 16.3 (vs air) |
| refractive index | n20/D 1.497 |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in , in anhydrous ethanol and in fatty oils. |
| form | neat |
| color | Clear yellow viscous liquid |
| Specific Gravity | 0.962 (20/4ºC) |
| Odor | Odorless |
| Water Solubility | Immiscible with water. |
| Sensitive | Air & Light Sensitive |
| Merck | 14,9495 |
| BRN | 97512 |
| InChIKey | ZAKOWWREFLAJOT-CEFNRUSXSA-N |
| CAS DataBase Reference | 7695-91-2(CAS DataBase Reference) |
| NIST Chemistry Reference | (+)-«ALPHA»-tocopherol acetate(7695-91-2) |
| EPA Substance Registry System | 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate (7695-91-2) |
| Safety Information |
| Safety Statements | 24/25 |
| WGK Germany | 1 |
| RTECS | GA8747000 |
| F | 8-10-23 |
| TSCA | Yes |
| HS Code | 29362800 |
| MSDS Information |
| Provider | Language |
|---|---|
| 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Tocopheryl acetate Usage And Synthesis |
| Chemical Properties | Light yellow to yellow clear liquid |
| Uses | anti-Altzheimer therapeutic |
| Uses | vitamin E acetate (tocopherol acetate) is an anti-oxidant with skinmoisturizing activity. given its free-radical scavenging properties, it is useful in uV protective products. Vitamin e acetate is commonly used to replace vitamin e because it is more stable and is converted to vitamin e by the body. |
| Hazard | A reproductive hazard. |
| Contact allergens | Tocopherol and tocopheryl acetate are used mainly as antioxidants. Tocopheryl acetate, an ester of tocopherol (vitamin E), can induce allergic contact dermatitis. |
| Purification Methods | It is a viscous liquid which is purified by distillation under high vacuum under N2 or Ar and stored in sealed ampoules in the dark. It is considerably more stable to light and air than the parent unacetylated vitamin. It is insoluble in H2O but freely soluble in organic solvents. All eight stereoisomers have been synthesised. The commercially pure d-tocopheryl acetate (2R,4'R,8'R) has b 180-200o/0.7mm and [] D 20 +3.9o (c 5, EtOH); see above. [Cohen et al. Helv Chim Acta 64 1158 1981, Beilstein 17/4 V 169.] |
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