Oleanolic Acid CAS No. 508-02-1 Oleanic Acid

• Customization: Available
• Certification: BRC, ISO
• Assay Method: HPLC, UV
• Model NO.: food grade
• Application Form: Lotion, Suppository, Paste, Tablet
• Application: Food, Health Care Products, Medicine
• State: Powder
• Extract Source: Oleanolic
• Store: Dry and Cool Place
• CAS No.: 508-02-1
• M F: C30h48o3
• M G: 456.71
• En No.: 208-081-6
• Transport Package: 25kg/Drum
• Specification: Food grade
• Trademark: JK
• Origin: China
• HS Code: 29181990
• Production Capacity: 100mt/Year

Product Description

Oleanolic Acid

Product Name: Oleanolic Acid,Olean-12-en-28-oic acid, 3-hydroxy-, (3β)-; Oleanol; CARYOPHYLLIN 
Botanical Source: Olea europaea l. 
Part Used: Leaf 
Specification: 98%Oleanolic Acid 
Appearance: Light Yellow Powder
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Description
Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid related to betulinic acid. It is widely distributed in food and plants where it exists as a free acid or as an aglycone of triterpenoid saponins.
 
Oleanolic acid can be found in olive oil, Phytolacca americana (American pokeweed), and Syzygium spp, garlic, etc. It was first studied and isolated from several plants, including Olea europaea (leaves, fruit), Rosa woodsii (leaves), Prosopis glandulosa (leaves and twigs), Phoradendron juniperinum (whole plant), Syzygium claviflorum (leaves), Hyptis capitata (whole plant), Mirabilis jalapa[4] and Ternstroemia gymnanthera (aerial part). Other Syzygium species including java apple (Syzygium samarangense) and rose apples contain it.
 
Main Function
1. Reduce liver damage: oleanolic acid as a pentacyclic triterpenoids, CCl4-induced acute and chronic liver injury in rats have a significant protective effect. After treatment, the enlarged mitochondria and dilated rough endoplasmic reticulum were restored. Liver cells can also be acute and chronic liver damage caused by balloon degeneration, necrosis and inflammatory response was significantly reduced. Liver triglyceride accumulation decreased, increased glycogen content.  
 
2. Lower serum alanine aminotransferase activity: oleanolic acid on acute, chronic hepatitis and liver cirrhosis animals were significantly decreased enzyme.  
 
3. Reduce serum r-globulin, and histological observation of the liver is consistent with the reduction of inflammatory response.
 
4. Promote the regeneration of liver cells: oleanolic acid can promote the number of rat liver residual mitotic phase was significantly increased, the regeneration of higher than the control group, suggesting a role in promoting cell regeneration.
 
5. Inhibition of hepatic fibrosis: Oleanolic acid treatment of liver fibrosis in rats, severe and significantly reduced hepatic fibrosis, liver collagen content decreased, suggesting that the role of prevention and treatment of cirrhosis.  
 
6. Chromosome damage has a protective effect on the prevention of experimental atherosclerosis, but also correct protein metabolism disorders.
 
Application Filed
1. Medicine
2. Health Food 






 

Oleanic acid Basic information

Description References

Product Name:	Oleanic acid
Synonyms:	Astrantigeninc;Caryophyllia;(4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptaMethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid;Oleanolic acid dihydrate, froM HeMsleya chinensis;Oleanolic acid >=97%;Oleanolic Acid Hydrate, 98.0%(T);Oleanolic acid, >=98%;Oleanolic Acid P.E.
CAS:	508-02-1
MF:	C30H48O3
MW:	456.71
EINECS:	208-081-6
Product Categories:	chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Terpenes;Terpenes (Others);Natural Plant Extract;Inhibitors;Pyrazoles;Pentacyclic triterpenes;Tri-Terpenoids;Biochemistry;Anti-proliferative AgentsAsymmetric Synthesis;Complex MoleculesNutrition Research;Isoprenoid/terpenoidCancer Research;Phase I Enzyme Inhibitors;Phase I Enzyme InhibitorsCancer Research;Biochemicals Found in Plants;Cancer Research;Chemopreventive Agents;Chiral Building Blocks;Multidrug Resistance;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol File:	508-02-1.mol

Oleanic acid Chemical Properties

Melting point	>300 °C(lit.)
alpha	D20 +83.3° (c = 0.6 in chloroform)
Boiling point	502.79°C (rough estimate)
density	1.0261 (rough estimate)
refractive index	1.4940 (estimate)
storage temp.	2-8°C
pka	2.52(at 25ºC)
form	neat
color	light yellow
Merck	14,6827
InChIKey	NZQIXFRGWXNLSP-IDYUENATSA-N
CAS DataBase Reference	508-02-1(CAS DataBase Reference)
EPA Substance Registry System	Oleanolic acid (508-02-1)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39-60-37
WGK Germany	2
RTECS	RK0177965
TSCA	Yes
HS Code	29181990

MSDS Information

Provider	Language
3beta-Hydroxyolean-12-en-28-oic acid	English
SigmaAldrich	English

Oleanic acid Usage And Synthesis

Description	Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid with the formula of C30H48O3. It was found in the non-glyceride fraction of olive pomace oil and is widely distributed in food and plants where it exists as a free acid or as an aglycone precursor for triterpenoid saponins, in which it can be linked to one or more sugar chains. It is biosynthesized from lupane. It can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin. Oleanolic acid and its derivatives possess several promising pharmacological activities, such as hepatoprotective effects, and anti-inflammatory, antioxidant, or anticancer activities.
References	1.https://jk-ingredients.en.made-in-china.com 2.https://www.ncbi.nlm.nih.gov/mesh/68009828 3.http://jk-ingredients.en.made-in-china.com 4.http://jk-ingredients.en.made-in-china.com
Chemical Properties	White Solid
Uses	A triterpenoid known for its anti-inflammatory properties, is commonly present in several medicinal plants.
Definition	ChEBI: A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.

Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on.
Our food additives and food ingredients, especially our Ascorbic Acid (Vitamin C), Acesulfame-K, Aspartame, Citrates, Dextrose, D-Xylose, Erythorbic Acid, Fumaric Acid, Fructose,Maltodextrin, Malic Acid, Monosodium glutamate, Lactic Acid Potassium Sorbate, Sodium Erythorbate, Sodium Cyclamate, Sodium Saccharin, sodium benzoate, Sodium ascorbate, Sorbic Acid, xanthan Gum, Xylitol, Tartaric Acid, I+G, , Vanillin, Sucralose, Stevia and so on, have been exported to more than 60 countries for our good quality products.
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