D-Calcium Pantothenate CAS No. 137-08-6 Calcium Pantothenate Vitamin B5

• Certification: QS, ISO
• Element: Vitamin B
• Shape: Powder
• Type: Acidifier
• Molecular Formula: C18h32can2o10
• Store: Dry and Cool Place
• Model NO.: food / feed grade
• Molecular Weight: 476.53
• CAS No.: 137-08-6
• Loading Port: Qingdao
• Loading Port 2: Shanghai
• Delivery: 15days
• Function: Vitamin Additives
• Transport Package: 25kg/Drum
• Specification: food/ feed grade
• Trademark: JK
• Origin: China
• HS Code: 293624
• Production Capacity: 100mt/Year

Product Description

Molecular Formula: C18H32CaN2O10
Molecular Weight: 476.53
Appearance : D-calcium pantothenate is a white or off-white powdery solid, odorless, slightly bitter, and hygroscopic. The aqueous solution is neutral or weakly alkaline. Soluble in water, soluble in glycerin, slightly soluble in acetone, methanol, ethanol, insoluble in ether, chloroform. Relatively stable under air and light.
Function and Character: D-calcium pantothenate is a vitamin B group substance, which is a component of coenzyme A and is widely used in medicine, food and feed industries.
Storage: sealed and stored to prevent sun, rain and moisture. Once the package is opened, please use it as soon as possible.
Validity: Unopened original packaging, can be stored for 36 months.

Usage

Use 1: As a food fortifier, can be used in infant foods, the dosage is 15~28mg/kg; in the drinking liquid is 2~4mg/kg.

Use 2: Biochemical research; nutrient composition of tissue culture medium. Clinically used to treat vitamin B deficiency, peripheral neuritis, postoperative intestinal colic.

Use 3: This product is a vitamin drug and is a component of Coenzyme A. Among the mixed calcium pantothenate, only the right-handed body has vitamin activity and participates in the metabolism of proteins, fats and sugars in the body. For vitamin B deficiency and peripheral neuritis, as well as post-operative colic. It can be used in combination with vitamin C to treat disseminated lupus erythematosus. The lack of calcium pantothenate in the human body has the following symptoms:
(1) Grth stops, weight loss, and sudden death.
(2) skin and hair disorders.
(3) Neurological disorders.
(4) Digestive organs disorders, liver dysfunction.
(5) affecting antibody formation.
(6) Paraneoplastic disorders. Every day, the human body needs about 5 mg of calcium pantothenate (as pantothenic acid).

Calcium pantothenate is used as a nutritional supplement for food processing. In addition to special nutritious foods, the amount used must be below 1% (calculated as calcium) (Japan). When the milk powder is fortified, it is 10 mg/100 g. Adding 0.02% to shochu and whisky enhances flavor. Adding 0.02% to honey prevents crystallization in winter. It can buffer the bitterness of caffeine and saccharin.

Use 4: The premise substance of biosynthesis of coenzyme A, due to the unstable characteristics such as the deliquescent of pantothenic acid, calcium salt is used as a substitute.

Vitamin Family
 

Product Name	CAS NO.
Cyanocobalamin	68-19-9
Mecobalamin	13422-55-4
Hydroxocobalamin	13422-51-0
Cobamamide	13870-90-1
Vitamin K1	84-80-0
Vitamin D2	50-14-6
Vitamin D3	67-97-0
Calcium Pantothenate	137-08-6
β-Carotene	7235-40-7
COENZYME Q10	303-98-0
Lycopene	502-65-8
Methylmethionine Sulfonium Chloride(Vitamin U )	1115-84-0
Lutein	127-40-2
Vitamin H Biotin	58-85-5

 

D-(+)-Pantothenic acid calcium salt Basic information

Nutritional supplement Production method Uses Toxicity Usage limit Chemical properties Hazards & Safety Information

Product Name:	D-(+)-Pantothenic acid calcium salt
Synonyms:	(+)-PANTOTHENIC ACID CALCIUM SALT;PANTOTHENIC ACID CALCIUM SALT;(R)-(+)-N-(2,4-DIHYDROXY-3,3-DIMETHYL-1-OXOBUTYL)-BETA-ALANINE HEMICALCIUM SALT;VITAMIN B5;VITAMIN B3/B5;(theta)-;beta-alanine,n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,calciumsalt(2:1),;N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,calciumsalt(2:1),(R)-.beta.-Alanine
CAS:	137-08-6
MF:	C18H32CaN2O10
MW:	476.53
EINECS:	205-278-9
Product Categories:	Biochemistry;Ca (Calcium) Compounds;Classes of Metal Compounds;Typical Metal Compounds;Vitamins;Nutritional Supplements;Nutritional fortification substances;Isolabel;Food additives;Pyridines ,Halogenated Heterocycles;Aliphatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	137-08-6.mol

D-(+)-Pantothenic acid calcium salt Chemical Properties

Melting point	190 °C
alpha	26.5 º (c=5, in water)
refractive index	27 ° (C=5, H2O)
Fp	145 °C
storage temp.	2-8°C
solubility	H2O: 50 mg/mL at 25 °C, clear, nearly colorless
form	Powder
color	White or almost white
PH	6.8-7.2 (25ºC, 50mg/mL in H2O)
optical activity	[α]20/D +27±2°, c = 5% in H2O
Water Solubility	Soluble in water.
Sensitive	Hygroscopic
Merck	14,7015
BRN	3769272
Stability:	Stable, but may be moisture or air sensitive. Incompatible with strong acids, strong bases.
InChIKey	FAPWYRCQGJNNSJ-UBKPKTQASA-L
CAS DataBase Reference	137-08-6(CAS DataBase Reference)
EPA Substance Registry System	Calcium pantothenate (137-08-6)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-37/38-41-48
Safety Statements	24/25-45-36/37/39-26-22
WGK Germany	1
RTECS	RU4375000
F	3-10
TSCA	Yes
HS Code	29362400

MSDS Information

Provider	Language
D-(+)-Pantothenic acid calcium salt	English
ACROS	English
SigmaAldrich	English
ALFA	English

D-(+)-Pantothenic acid calcium salt Usage And Synthesis

Nutritional supplement	D-Calcium pantothenate as components of coenzyme A regulates the metabolism of protein, saccharide, and fat, and prevents diseases, which is indispensable substance for growth and development of domesticated creatures and fishes, for fatty synthesis and decomposition. The lack of D-calcium pantothenate would result in the slow growth of poultry and the malfunction of reproduction mechanisms. Therefore, D-calcium pantothenate as a growth far is used in feed additives. In addition, D-calcium pantothenate is also as food enrichment widely used in food industries, sun as breakfast cereals, beverages, dietetic, and baby foods. D-Calcium pantothenate has the function of making antibodies and it plays an important role in the fight against pressure to maintain hair, skin and blood health, and also contributes to improving the deficiency and neuritis. Thus, it has broad medical value and has been applied in pharmaceutical industries that single-dose is used for pantothenic acid deficiency, complex of vitamins B and multivitamins are used for vitamin supplement, and other compounds with different components are widely used for gastrointestinal diseases, respiratory diseases, skin diseases, mental inactivity, neurasthenia, and so on.
Production method	Take isobutyraldehyde as raw material; carry out hydroxymethylation, addition reaction, hydrolysis, acidification, lactonization and acylation to derive the final product.  Formaldehyde and anhydrous potassium carbonate are sent into the reaction pot. At 14-20 °C, it is added dropwise of isobutyraldehyde. After the completion of the addition, incubate for stirring reaction for 3h, and then stand at 14-18 °C for 0.5 h to obtain the upper oil-2, 2-dimethyl-3-hydroxypropionaldehyde. 2, 2-dimethyl-3-hydroxypropanal is dissolved in 4 times the water while the sodium cyanide is dissolved in 6 times the water and calcium chloride dissolved in 2 times the water. The above solutions are successively added into the reaction pot. 50% sulfuric acid solution was added under stirring at 60-65 ° C for 6h; then being heated to 80-85 °C for 3h and subject to vacuum concentration to being thick. 95% ethanol was added to precipitate the inorganic salt and filtrate. After the recovery of ethanol through distillation under reduced pressure, collect the fractions of 130-145C (1.33-2.39 Kpa), namely ?-butyrolactone. Then, β-aminopropionic acid, 5/6 methanol and lime were successively added to the reactor. Raise the temperature to 40 °C, and the reaction was stirred for 2 hours. The reaction mixture was allowed to stand for while before the supernatant was filtered by filtration. The solid residue in the pot was washed with 1/6 methanol and then filtered. The filtrate is placed in another reaction pot, being added of γ-butyrolactone for stirring and dissolving in room temperature for 40 h reaction to generate calcium pantothenate. Stirring with water and cooling to-5-0 °C, and add seed crystal for stirring of 24 hours, filter to obtain the dextro calcium pantothenate. 2/3 the amount of calcium pantothenate and calcium p-pantothenate are thrown into the reaction pot; add methanol and water, heat to 40 °C for stirring dissolving and filter upon being hot. The filtrate is cooled to 15 °C, added of a small amount of calcium L-pantothenate and crystal for 2h. When the specific rotation is up to +6 °-+8 °, separate the crystal, and wash with a small amount of methanol to obtain the L-calcium p-pantothenate (still used for resolution). The remaining 1/3 racemic calcium pantothenate was dissolved in a filtrate of 35-40 ° C, filtered and cooled to 15 ° C. A small amount of calcium p-pantothenate was added and the crystals were incubated for 2 hours. Crystals were separated when the specific rotation was-0.8 °--0.6 °, washed with a small amount of methanol and dried in vacuo to give calcium dextrate. It is derived through the heating and condensation between calcium β-alanine and α-hydroxy β, β-dimethyl-γ-butyl ester.
Uses	1.    It can be applied to biochemical studies; as the nutrient composition of tissue culture medium. It is clinically used for the treatment of vitamin B deficiency, peripheral neuritis and postoperative colic. 2.    It can be used as food fortifier, also used as infant food with the usage amount of 15~28 mg/kg; it is 2~4mg/kg in the drink. 3.    This product is a vitamin drugs, being an integral part of coenzyme A. In the mixture of calcium pantothenate, only the right-hand body has vitamin activity, participating into the in vivo metabolism of protein, fat and carbohydrate. It can be used for the treatment of vitamin B deficiency and peripheral neuritis, and postoperative colic. Its combined treatment with vitamin C can be used for the treatment of disseminated lupus erythematosus. The lack of calcium pantothenate in human body has the following symptoms: (1) growth arrest, weight loss and sudden death. (2) Skin and hair disorders. (3) Neurological disorders. (4) Digestive disorders, liver dysfunction. (5) Affect the antibody formation. (6) Kidney dysfunction. Every day the body demands 5 mg of calcium pantothenate (calculated based on pantothenic acid). Calcium pantothenate, as a nutritional supplement, can be used for the food processing. In addition to special nutritional food, the usage amount should be below 1% (calculated on calcium) (Japan). Upon the strengthening of the milk powder, the usage amount should be 10 mg/100g. Addition of 0.02% into the Shochu and whiskey can further enhance the flavor. Addition of 0.02% into the honey can prevent the winter crystallization. It can be used for buffering the bitterness of caffeine and saccharin. 4.    It can be used as feed additives, food additives, being in line with Pharmacopoeia USP28/BP2003 5.    It can be used as nutritional supplements, being able to enhance the flavor of shochu whiskey to prevent the crystallization of honey in winter. 6.    It is the precursor product for the biosynthesis of coenzyme A. Because of the easy-deliquescence of pantothenic acid and other unstable properties, it is used of calcium salt as the substitute.
Toxicity	LD50>10 g/kg (rat, oral); GRAS (FDA, § 182.5212, §184.1212, 2000);
Usage limit	GMP as the limit (FDA &184.1212, 2000); 1% in general food (calculated based on calcium excluding special nutritional supplements; Japan, 1993);
Chemical properties	It appears as white crystalline (methanol), being hygroscopic; it is stable to the light and air with its aqueous solution being weakly alkaline. Its Mp is 195-196 °C (decomposition); Specific rotation [α] 26D + 28.2 ° (5%, water); It is soluble in water and glycerol, being slightly soluble in acetone and ethanol;
Hazards & Safety Information	Category: Toxic substances Toxicity classification: Low toxicity Acute toxicity: Oral-rat LD50: 10000 mg/kg; oral-mouse LD50: 10000 mg/kg Flammability and Hazardous characteristics: Thermal decomposition releases toxic nitrogen oxides Storage and transport characteristics Treasury: low temperature, ventilated and dry Fire extinguishing agent:  water, carbon dioxide, dry powder, foam
Chemical Properties	D-(+)-Pantothenic acid calcium salt is white crystalline powder
Uses	D-(+)-Pantothenic acid calcium salt is a member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources.
Uses	calcium pantothenate is used as an emollient and to enrich creams and lotions in hair care preparations. This is the calcium salt of pantothenic acid found in liver, rice, bran, and molasses. It is also found in large amounts in royal jelly.
Uses	Calcium Pantothenate is a nutrient and dietary supplement which is the calcium chloride double salt of . It is a white powder of bitter taste and has a solubility of 1 g in 3 ml of water. It is used in special dietary foods.
General Description	The first suggestion for the existance of vitamin B5 came from Carter et al. in 1930; although it was never characterized or isolated. This vitamin is synthesized by most green plants and microorganisms. Excellent sources of the vitamin are liver, egg yolk, whole grains, and fortified ready-to-eat cereals. However, as the original name implies, many foods contain sufficient pantothenic acid to supply dietary needs.  Chemically, pantothenic acid is considered to be aβ-alanine derivative of the asymmetric pantoic acid and thus shows asymmetry. Only the naturally occurring D(+)- stereoisomer (with R configuration) is biologically active and the L(-)-stereoisomer (with S configuration) is inactive. When its carboxylate functional group is attached through an amide linkage with β-mercaptoethylamine, it is known as pantetheine (also spelled pantotheine). The biologically active form of pantothenic acid, CoA, is formed when the terminal alcoholic function of pantetheine is attached to ADP 3'-phosphate.
Clinical Use	The only therapeutic indication for pantothenic acid is intreatment of a known or suspected deficiency of this vitamin.Because of the ubiquitous nature of pantothenic acid, deficiencystates of this vitamin are only seen experimentally byuse of synthetic diets devoid of the vitamin, by use of thevitamin antagonist, ω-methylpantothenic, or both. In a 1991review, Tahiliani and Beinlich described that the mostcommon symptoms associated with pantothenic acid deficiencywere headache, fatigue, and a sensation of weakness.Sleep disturbances and gastrointestinal disturbances, amongothers, were also noted. The most likely setting for pantothenicacid deficiency is in the setting of alcoholism wherea multiple vitamin deficiency exists confounding the exactrole of the pantothenic acid deficiency as compared to theother vitamins. Because a deficiency of a single B vitamin israre, pantothenic acid is commonly formulated in multivitaminor B-complex preparations.
Safety Profile	Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. A vitamin. See also CALCIUM COMPOUNDS. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods	The salt crystallises as needles from MeOH, EtOH or isoPrOH (with 0.5mol of isoPrOH). It is moderately hygroscopic. The S-benzylisothiuronium salt has m 151-152o (149o when crystallised from Me2CO). [Kagan et al. J Am Chem Soc 79 3545 1957, Wilson et al. J Am Chem Soc 76 5177 1954, Stiller & Wiley J Am Chem Soc 63 1239 1941, Beilstein 4 IV 2569.]

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