Betadex Sulfobutyl Ether Sodium is a sodium salt produced when betacyclodextrin is alkylated by 1,4-butanesulfonic acid lactone under alkaline conditions. It is an anion, highly water-soluble betacyclodextrin derivative. Betadex Sulfobutyl Ether Sodium is can be well combined with the drug molecules to form non-covalent complex, thereby enhancing the stability, water solubility, and safety of the drug, reducing its renal toxicity, easing drug hemolysis, controlling drug release rate, covering bad smell, etc. Compared with betacyclodextrin, sulfobutyl betacyclodextrin sodium has a higher water solubility, smaller hemolytic effect, and lower renal toxicity, which make it a new pharmaceutical excipient with very broad application prospects.
| Betadex Sulfobutyl Ether Sodium ( EP9.6) |
| CONTENT |
| SULFOBUTYLBETADEX SODIUM |
98.0%-102.0% |
| AVERAGE DEGREE OF SUBSTITUTION |
5.9-6.6 |
| CHARACTERS |
| APPEARANCE |
white or almost white, hygroscopic powder |
| SOLUBILITY |
freely soluble in water, practically insoluble in anhydrous ethanol and in methylene chloride |
| IDENTIFICATION |
| A INFRAED ABSORPTION SPECTROPHOTOMETRY |
same absorption bands. the relative intensity of some absorption bands may vary. |
| B SODIUM REACTION |
it gives reaction (a) of sodium |
| TEST |
| PH |
5.0-7.5 |
| APPEARANCE OF SOLUTION |
clear and colorless |
| REDUCING SUGARS |
NMT 0.05% |
| IMPURITIES |
| Limit of betadex |
NMT 0.1% |
| Limit of 1'2λ6-oxathiane-2,2-dione |
NMT 0. 5ppm |
| Limit of 4-hydroxybutane-1-sulfonic acid |
NMT 0. 1% |
| Limit of 4,4'-oxydi(butane-1-sulfonic acid) |
NMT 0. 05% |
| LIMIT OF SODIUM CHLORIDE |
NMT 0.20% |
| WATER |
NMT10.0% |
| MICROBIAL CONTAMINATION |
| the total aerobic microbial count |
NMT 100cfu/g |
| the total combined molds and yeasts count |
NMT 100cfu/g |
| Escherichia coli. |
absence |
| Salmonella |
absence |
| Natural Cyclodextrin; |
| Alpha-Cyclodextrin |
Beta-Cyclodextrin |
Gamma-Cyclodextrin |
| Alpha Cyclodextrin Derivatives; |
| Hydroxypropyl-Alpha-Cyclodextrin |
Sulfobutylether-Alpha-Cyclodextrin |
| Beta Cyclodextrin Derivatives; |
|
| Hydroxypropyl-Beta-Cyclodextrin |
Sulfobutyl ether-Beta-Cyclodextrin Sodium |
| Piroxicam-Beta-Cyclodextrin |
Glucosyl-Beta-Cyclodextrin |
| Hydroxyethyl-Beta-Cyclodextrin |
Carboxymethyl-Beta-Cyclodextrin |
| Hydroxypropyl-Beta-Cyclodextrin |
2,6-Dimethyl-Beta-Cyclodextrin |
| 2-Hydroxypropyl-Beta-Cyclodextrin |
Methyl-Beta-Cyclodextrin |
| Gamma Cyclodextrin Derivatives; |
| Hydroxypropyl-Gamma-Cyclodextrin |
Sulfobutylether-Gamma-Cyclodextrin |
| Cyclodextrin Inclusion Compounds |
| Soluble inclusion compound of pueraria flavones |
Soluble inclusion compound of Gynostemma Extract |
| Plant essential oil inclusion compound |
Flavor inclusion compound |
| Rotation substance separation reagent |
| Chromatogram filler: cyclodextrins. |
| β-Cyclodextrin, sulfobutyl ethers, sodium salts Basic information |
| Product Name: |
β-Cyclodextrin, sulfobutyl ethers, sodium salts |
| Synonyms: |
CAPTISOL;Sodium sulfobutylether β-cyclodextrin;Betadex Sulfobutyl Ether Sodium (500 mg);sulfobutyl ether B-cyclodextrin;sodiuM salts;sulfobutyl ethers;SodiuM Sulphobutylether-β-Cyclodextrin;CAPTISOL,BETA-CYCLODEXTRIN SULFOBUTYL ETHERS, SODIUM SALT |
| CAS: |
182410-00-0 |
| MF: |
C42H70O35 |
| MW: |
1134.9842 |
| EINECS: |
1308068-626-2 |
| Product Categories: |
|
| Mol File: |
182410-00-0.mol |
| |
| |
| β-Cyclodextrin, sulfobutyl ethers, sodium salts Chemical Properties |
| solubility |
Soluble in water. Insoluble in acetone, methanol, chloroform. |
| form |
Solid powder |
| color |
White to off white |
| |
| β-Cyclodextrin, sulfobutyl ethers, sodium salts Usage And Synthesis |
Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on.
Our food additives and food ingredients, especially our Ascorbic Acid (Vitamin C), Acesulfame-K, Aspartame, Citrates, Dextrose, D-Xylose, Erythorbic Acid, Fumaric Acid, Fructose,Maltodextrin, Malic Acid, Monosodium glutamate, Lactic Acid Potassium Sorbate, Sodium Erythorbate, Sodium Cyclamate, Sodium Saccharin, sodium benzoate, Sodium ascorbate, Sorbic Acid, xanthan Gum, Xylitol, Tartaric Acid, I+G, , Vanillin, Sucralose, Stevia and so on, have been exported to more than 60 countries for our good quality products.
Our staff of sales and technical support is available to help you in selecting the right protection for your application as well as to provide you with samples of our products for evaluation. At High Five, we are committed to providing the highest level of customer service, competitive pricing, speedy delivery and a comprehensive, cutting-edge product offering. Our ultimate goal is your satisfaction.
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