Product Name: Tangerine Peel Extract
Botanical Name: Pericarpium Citri Reticulatae
Part Used: Bark
Specification: 4: 1, 10: 1, 12: 1, 90%, 92%, 95%, 98% Hederagenin
Test method: TLC, UV
CAS No.: 520-26-3
Molecular Formula: C28H34O15
Molecular Weight: 610.57
Appearance: Fine pale yellow powder
Where will NutraMax 's Tangerine Peel Extract used to?
Antioxidant activity;
Protective effects against sepsis;
Anti-inflammatory effects;
Anticancer activity;
A potential sedative;
Reduced cholesterol and blood pressure in rats
Application of NutraMax 's Tangerine Peel Extract
(1). Applied in food field, various foods are use it as the materials;
(2). Applied in pharmaceutical field, it is made into tablet or capsule, which is often used for eat less and coughing much sputum;
(3). Applied in cosmetic field, many sorts of orange peel oil can nourish the skin.
NutraMax's Technological Process:
Raw Material - Immersion in water - Filtering - Purification - Concentration in Vacuum - Killing of Bacteria - Drying - Powder
Certificate: ISO9001, KOSHER, HALAL
Srorage: Stored in dry and cool place, keep away from strong light and heat.
Shelf Life: Two years when properly stored.
| Items |
Specification |
| Appearance |
Fine pale yellow powder |
| Oder |
Characteristic |
| Taste |
Characteristic |
| Paiticle size |
Pass 80 mesh |
| Loss on drying |
≤5% |
| Heavy metals |
<10ppm |
| As |
<1ppm |
| Pb |
<3ppm |
| Assay |
Result |
| Protodioscin |
≥45% |
| Total Plate Count |
<10000cfu/g or <1000cfu/g(Irradiation) |
| Yeast & Mold |
<300cfu/g or 100cfu/g(Irradiation) |
| E.Coli |
Negative |
| Salmonella |
Negative |
| Hesperidin Basic information |
| Hesperidin Pharmacological activity Industry Status Chemical Properties Uses Production method |
| Product Name: |
Hesperidin |
| Synonyms: |
Hesperidin 520-26-3;Diosmin EP Impurity B;Diosmin EP Impurity B(Hesperidin);HESPERIDINE;HESPERETIN-1-RHAMNOSIDO-D-GLUCOSE;HESPERETIN-7-O-RUTINOSIDE;HESPERETIN-7-RHAMNOGLUCOSIDE;HESPERETIN-7-RUTINOSIDE |
| CAS: |
520-26-3 |
| MF: |
C28H34O15 |
| MW: |
610.56 |
| EINECS: |
208-288-1 |
| Product Categories: |
Flavanones;plant extract;Antioxidant;Biochemistry;Disaccharides;Flavonoids;Glycosides;Sugars;Natural Plant Extract;natural product;Inhibitors;Carbohydrates & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: |
520-26-3.mol |
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Hesperidin Chemical Properties |
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| Melting point |
250-255 °C (dec.)(lit.) |
| alpha |
-76 º (c=2,pyridine) |
| Boiling point |
576.16°C (rough estimate) |
| density |
1.3290 (rough estimate) |
| refractive index |
1.5940 (estimate) |
| storage temp. |
2-8°C |
| pka |
7.15±0.40(Predicted) |
| form |
Powder |
| color |
light brown |
| Water Solubility |
Insoluble in water. Soluble in organic solvents such as DMSO. |
| Sensitive |
Hygroscopic |
| Merck |
14,4671 |
| BRN |
75140 |
| Stability: |
Stable. Incompatible with strong oxidizing agents. |
| InChIKey |
QUQPHWDTPGMPEX-QJBIFVCTSA-N |
| CAS DataBase Reference |
520-26-3(CAS DataBase Reference) |
| EPA Substance Registry System |
Hesperidin (520-26-3) |
| Hazard Codes |
Xi |
| Risk Statements |
22-36/37/38 |
| Safety Statements |
22-24/25-36/37/39-27-26 |
| WGK Germany |
3 |
| RTECS |
MK6650000 |
| F |
3-10 |
| TSCA |
Yes |
| HS Code |
29389090 |
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MSDS Information |
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| Provider |
Language |
| Hesperidin |
English |
| SigmaAldrich |
English |
| ACROS |
English |
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| Hesperidin Usage And Synthesis |
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| Hesperidin |
Hesperidin (glycoside) is a flavonoid substance which has flavanone oxygen glycoside structure. It is weakly acidic with pure being white needle-like crystals. It is also the main component of vitamin P.
Figure 1 the molecular structure of hesperidin.
After the hydrogenation, hesperidin becomes a natural sweetener, dihydrochalcone, whose sweetness is 1,000 times as high as sucrose. It can be used as a functional food for application. Hesperidin has a variety of biological characteristics. Modern research has found that: hesperidin has various effects such as antioxidant, anti-cancer, anti-mildew, anti-allergy, lowering blood pressure, inhibiting oral cancer and esophageal cancer, maintenance of osmotic pressure, increasing capillary toughness, and lowering cholesterol. Related studies have shown that hesperidin has broad antibacterial spectrum on common food contamination. It has significant inhibitory effect on Bacillus subtilis, Salmonella typhimurium, Shigella bacteria, hemolytic streptococcus and Vibrio cholerae. Therefore, it is widely applied in food additives and food processing. |
| Pharmacological activity |
1. Hesperidin is a kind of drug for treatment of hypertension and myocardial infarction. It is used as the pharmaceutical raw material in the pharmaceutical industry and is one of the main components of a Chinese patent medicine, beniol.
2. Hesperidin has various effects such as anti-lipid oxidation, scavenging oxygen free radicals, and anti-inflammatory, anti-viral, anti-bacterial. Long-term use can delay aging and cancer. In short, hesperidin is a kind of flavonoids with clear defined pharmacological activity as well as extensive function of flavonoids. In addition to its application in medicine, it also has wide application in sports pharmacy and sports nutrition and therefore has broad prospects of development and utilization. Its related research work is expected to subject to further deepening. |
| Industry Status |
Hesperidin has various effects such as maintaining osmotic pressure, increasing capillary toughness, shortening the bleeding time, and reducing the cholesterol. It is clinically used for the adjuvant treatment of cardiovascular diseases. It can be used for cultivating various kinds of drugs for preventing arteriosclerosis and myocardial infarction. It is one of the major raw materials for synthesizing Chinese patent medicine "beniol". It can be used as natural antioxidants in the food industry and can also be used in the cosmetics industry.
Hesperidin is mostly presented in the waste of citrus processing such as fruit skin and fruit bag with the highest content being presented in mature skin and tissue (30%-50% in the peel, orange envelope, nuclear, pulp contains 30%-50%, epicarp contains 10%-20%). Orange juice and capsule contain a relative low amount being 1% to 5%. Extraction methods of hesperidin include solvent extraction, alkaline extraction and acid precipitation, carbon adsorption, ion exchange, wherein the alkali extraction and acid precipitation method is simple, low-cost, and has a high extraction rate. Hesperidin can be dissolved in dilute alkali and pyridine as well as hot water (over 70 °C). It is also slightly soluble in methanol but almost insoluble in acetone, benzene and chloroform. The extraction of hesperidin mainly take advantage of its two phenolic hydroxyl groups which under alkaline conditions, has reaction with the sodium ion in the solution to generate sodium salt to be dissolved out; then acidify, cool to precipitate it from solution. Extraction of hesperidin from citrus peels commonly adopts heat extraction and soaks extraction method with a non-idea yield. In recent years, studies on the ultrasonic extraction of the effective components from natural plants (especially herbs) have been widely carried out, and have already obtained some progress. The extraction is first based on the hesperidins' ring-opening dissolution under alkaline conditions and then further loop closure precipitation for being separated out under acidic conditions. During the extraction process, increasing the amount of the alkali can reduce the necessary amount of ethanol. But it is not recommended to apply a relative large amount of alkaline otherwise hesperidin is easily susceptible to oxidation damage.
Figure 2 Yellow powder of hesperidin
The above information is edited by the Chemicalbook of Dai Xiongfeng. |
| Chemical Properties |
It is light yellow crystalline powder with melting point being 258-262 °C (soften at 252 °C). It is easily soluble in pyridine, sodium hydroxide solution; soluble in dimethyl formamide; slightly soluble in methanol and hot glacial acetic acid; very slightly soluble in ether, acetone, chloroform and benzene.1g of this product can be dissolved in 50L water. It is odorless and tasteless. |
| Uses |
The product is a vitamin P type medicine. It is mainly used to enhance the toughness of capillaries. The derivative of hesperidin, methyl hesperidin is also vitamin P type medicine. It has been listed in as a variety in Japan'sJapanese Standard of food additives.
It is a vitamin drug which can reduce the fragility of capillary used for the adjuvant treatment of hypertension. |
| Production method |
The product is presented in the pericarp of lemon, citrus, and Citus aurantium. In citrus, the developed system of the mesocarp (white spongy tissue) mostly contains citrus glycosides.. Instead thinner system of mesocarp mostly contains hesperidin. The product is mainly extracted from the dried, ripe orange peel. Crush the dry orange peel; add 3-6 times the amount of water to soak for about 0.5h to make it soft. Then add 4-10% of the amount of lime and 7-12 times the amount of water; stir uniformly and check the pH. The pH value should reach 11.5-12, otherwise we should supplement lime or sodium hydroxide. After soaking for 1.5-2h, centrifuge and filter with the residues adding 5-7 times the amount of water and further adjust to pH 11.5-12 with proper amount of lime; continue soaking and centrifuge and filter again. After the clarification of the filtrate, add diluted hydrochloric acid for adjusting pH to 5; stand for 2d; collect the precipitate and wash with water to nearly neutral which give the crude product. Add 1% of sodium hydroxide and 50% of ethanol to dissolve the crude product; filter and adjust the filtrate to pH 5 with dilute hydrochloric acid, stand overnight, and collect the precipitate; first wash once with 50% ethanol, and then wash with water to nearly neutral; dry at 70 °C; pulverize and sieve to obtain hesperidin with the total yield being 0.6-1.8%. |
| Chemical Properties |
light brown powder |
| Uses |
A flavanone found in citrus fruits, also regarded as Vitamin P. |
| Uses |
antiinflammatory, capillary protectant, hypolipidemic |
| Uses |
Anticancer |
| Uses |
vitamin P is considered a vascular protector and an anti-inflammatory agent, vitamin P is said to promote capillary health and increase resistance to collagen destruction. Vitamin P is a bioflavonoid that can work in conjunction with vitamin C, helping prevent oxidation of the latter. Vitamin P is found in such food sources as apricots, broccoli, citrus fruit pulp, grapes, prunes, and spinach. |
| Uses |
Hesperidin is a flavoring agent that is a bioflavonoid found in citrus pulp. it has minor use as a flavorant. |
| Definition |
ChEBI: A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. |
| Purification Methods |
Dissolve hesperidine in dilute aqueous alkali and precipitate it by adjusting the pH to 6-7. [Beilstein 18 III/IV 3219, 18/5 V 218.] |
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| Hesperidin Preparation Products And Raw materials |
| Raw materials |
LIMONIN(SH)-->Polyurethane foam plastic-->HIDE POWDER |
| Preparation Products |
ETHYL LINOLEATE-->BETA-PHENYLPROPIOPHENONE |
Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on.
Our food additives and food ingredients, especially our Ascorbic Acid (Vitamin C), Acesulfame-K, Aspartame, Citrates, Dextrose, D-Xylose, Erythorbic Acid, Fumaric Acid, Fructose,Maltodextrin, Malic Acid, Monosodium glutamate, Lactic Acid Potassium Sorbate, Sodium Erythorbate, Sodium Cyclamate, Sodium Saccharin, sodium benzoate, Sodium ascorbate, Sorbic Acid, xanthan Gum, Xylitol, Tartaric Acid, I+G, , Vanillin, Sucralose, Stevia and so on, have been exported to more than 60 countries for our good quality products.
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