| Powder: | Yes |
|---|---|
| Customized: | Non-Customized |
| Certification: | ISO 9001 |
| Suitable for: | Children, Adult |
| State: | Solid |
| Purity: | >98% |
| Samples: |
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| Customization: |
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Audited Supplier | Product Name | gamma cyclodextrin | ||
| Batch No. | 20200625 | Invoice Date. | |
| Quantity | 1000kg, 40bags | MFG Date: | june 25, 2020 |
| Contract No. | EXP date | june 24, 2022 | |
| ITEM | STANDARD | RESULTS | |
| Appearance | White or almost white, amporphous or crystalline powder. Freely soluble in water and in proene glycol; very slight soluble in alcohol. | Complied | |
| Identification | IR | Same absorption bands as USP Gamma Cyclodextrin RS | Complied |
| HPLC | The retention time of the major peak of sample solution corresponds to the standard solution. | Complied | |
| Optical rotation | +174°--- +180° | +175° | |
| Residue on ignition | ≤0.1 % | 0.1 | |
| Reducing substance | ≤0.5 % | 0.09 | |
| Alpha cyclodextrin | ≤0.5% | Not detected | |
| Betadex cyclodextrin | ≤0.5 % | Not detected | |
| Sum of other impurities | ≤0.5 % | Not detected | |
| Loss on drying | ≤11.0 % | 9.0 | |
| Color and Clarity of solution | At 420 nm, the absorbance is not greater than 0.20, and the solution | Complied | |
| Assay | 98.0%----102.0% | 99.3 | |
| The total aerobic microbial count | ≤1000 cfu/g | 20 cfu/g | |
| The total combined moulds and yeasts count | ≤100 cfu/g | Not detected | |
Gamma cyclodextrin CAS No 17465-86-0
Gamma Cyclodextrin pharmaceutical grade applications:
1). In pharmaceutical field, Gamma Cyclodextrin pharmaceutical grade and medicine could produce inclusion compound,
which could: A. make unstable medicine stable; B. make deliquescing, sticky and liquid medicine
more powder-like; C. make insoluble or hard-soluble medicine soluble.
2). In pesticide field, Gamma Cyclodextrin pharmaceutical grade and medicine could produce inclusion compound
to make some pesticides store and increase insecticidal efficacy.
3). In food field,Gamma Cyclodextrin pharmaceutical grade could: A. cover and remove peculiar smell;B. improve
and enhance food organization structure; C. relieve and remove bitter and astringent;
D. anti-oxidation; E. keep and improve relish.
4). In daily chemical field, Gamma Cyclodextrin pharmaceutical grade could function as emulgator and quality improver in cosmetics production. It could also be applied in tooth paste and tooth powder
as deodorant and preservative.
5). In environment-protection field, Gamma Cyclodextrin pharmaceutical grade could be applied as treatment of waste water with oil. Alpha Cyclodextrin water solution could be used to clean oil groove
and recycle it to get fuel oil.
| Natural Cyclodextrin; | |||
| Alpha-Cyclodextrin | Beta-Cyclodextrin | Gamma-Cyclodextrin | |
| Alpha Cyclodextrin Derivatives; | |||
| Hydroxypropyl-Alpha-Cyclodextrin | Sulfobutylether-Alpha-Cyclodextrin | ||
| Beta Cyclodextrin Derivatives; | |||
| Hydroxypropyl-Beta-Cyclodextrin | Sulfobutyl ether-Beta-Cyclodextrin Sodium | ||
| Piroxicam-Beta-Cyclodextrin | Glucosyl-Beta-Cyclodextrin | ||
| Hydroxyethyl-Beta-Cyclodextrin | Carboxymethyl-Beta-Cyclodextrin | ||
| Hydroxypropyl-Beta-Cyclodextrin | 2,6-Dimethyl-Beta-Cyclodextrin | ||
| 2-Hydroxypropyl-Beta-Cyclodextrin | Methyl-Beta-Cyclodextrin | ||
| Gamma Cyclodextrin Derivatives; | |||
| Hydroxypropyl-Gamma-Cyclodextrin | Sulfobutylether-Gamma-Cyclodextrin | ||
| Cyclodextrin Inclusion Compounds | |||
| Soluble inclusion compound of pueraria flavones | Soluble inclusion compound of Gynostemma Extract | ||
| Plant essential oil inclusion compound | Flavor inclusion compound | ||
| Rotation substance separation reagent | |||
| Chromatogram filler: cyclodextrins. | |||
| Cyclooctapentylose Basic information |
| Product Name: | Cyclooctapentylose |
| Synonyms: | CYCLOFLO(TM) 42;CYCLOOCTAOSE;CYCLOOCTAAMYLOSE;CYCLOMALTOOCTAOSE;GAMMA-CYCLODEXTRIN;SCHARDINGER GAMMA-DEXTRIN;cyclooctapentylose;gamma-Cyclodextrin Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.0-102.0% cyclodextrin basis |
| CAS: | 17465-86-0 |
| MF: | C48H80O40 |
| MW: | 1297.12 |
| EINECS: | 241-482-4 |
| Product Categories: | Alcohols;Building Blocks;C11 to C30+;C20 to C60+;Chemical Synthesis;Ethers;Organic Building Blocks;Oxygen Compounds;Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Dextrins,Sugar & Carbohydrates |
| Mol File: | 17465-86-0.mol |
| Cyclooctapentylose Chemical Properties |
| Melting point | ≥300 °C |
| alpha | [α]D25 +174~+179° (c=1, H2O) (After Drying) |
| Boiling point | 845.2°C (rough estimate) |
| density | 1.2064 (rough estimate) |
| refractive index | 1.7500 (estimate) |
| Fp | 450ºC |
| solubility | 1 M NaOH: 25 mg/mL, may be clear to slightly hazy |
| pka | 11.68±0.70(Predicted) |
| form | powder |
| color | white |
| optical activity | [α]/D 174.0 to 180.0° |
| Water Solubility | 232g/L(25 ºC) |
| λmax | λ: 420 nm Amax: ≤0.20 |
| Merck | 14,2718 |
| BRN | 5725162 |
| InChIKey | GDSRMADSINPKSL-HSEONFRVSA-N |
| EPA Substance Registry System | .gamma.-Cyclodextrin (17465-86-0) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25-22 |
| WGK Germany | 2 |
| RTECS | GU2293080 |
| F | 3 |
| HS Code | 29400000 |
| Cyclooctapentylose Usage And Synthesis |
| Chemical Properties | White powder or crystal |
| Chemical Properties | Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders. |
| Production Methods | Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected. |
| Pharmaceutical Applications | Cyclodextrins are 'bucketlike' or 'conelike' toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex. Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability. Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material. γ-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules;it has low toxicity and enhanced water solubility. In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent. In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation. Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics. |
| Safety | Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations. Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity. Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries. Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic. γ-Cyclodextrin LD50 (rat, IP): 4.6 g/kg LD50 (rat ,IV): 4.0 g/kg LD50 (rat, oral): 8.0 g/kg |
| storage | Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity. |
| Regulatory Status | Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections). Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA. |
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