Mono-Ammonium Glycyrrhizinate (MAG)
Chinese Name:Mono-Ammonium Glycyrrhizinate (MAG)
CAS:53956-04-0
Application:,.
Loss on Drying:≤6.00%
Residue on Ignition:≤0.20%
Assay:Titr: 98%-102% HPLC≥73%
Notes:Mono-Ammonium Glycyrrhizinate is a high purity natural sweetener, with a sweetness 200-300 times stronger than that of sucrose. QHL Pharmaceuticals has eliminated the bitterness and other unwanted flavours by improving the production process. Therefore, the taste of MAG is now much longer lasting.
| Glycyrrhizic acid ammonium salt Basic information |
| Product Name: |
Glycyrrhizic acid ammonium salt |
| Synonyms: |
monoammoniumglycyrrhetat;Monoammoniumglycyrrhetate;monoammoniumglycyrrhizate;GLYCAMIL;GLYCYRRHIZIC ACID AMMONIUM SALT;GLYCYRRHIZIC ACID, NH4;GLYCYRRHIZIC ACID, NH4+;GLYCYRRHIZIN AMMONIACAL |
| CAS: |
53956-04-0 |
| MF: |
C42H65NO16 |
| MW: |
839.96 |
| EINECS: |
258-887-7 |
| Product Categories: |
Herb extract;API;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Organics;Biochemistry;Disaccharides;Glycosides;Sugars;Natural Plant Extract;The group of Liquorice;Inhibitors;Pyridines |
| Mol File: |
53956-04-0.mol |
| |
| |
| Glycyrrhizic acid ammonium salt Chemical Properties |
| Melting point |
>200°C (dec.) |
| Boiling point |
768.56°C (rough estimate) |
| density |
1.1846 (rough estimate) |
| FEMA |
2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) |
| refractive index |
49 ° (C=1.5, EtOH) |
| storage temp. |
2-8°C |
| solubility |
Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides. |
| form |
Powder or Crystals |
| color |
Yellow to yellow-green |
| optical activity |
[α]20/D +48±4°, c = 1% in ethanol: water (1:1) |
| BRN |
3897076 |
| InChIKey |
ILRKKHJEINIICQ-YDYGGSECSA-N |
| CAS DataBase Reference |
53956-04-0 |
| EPA Substance Registry System |
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt (53956-04-0) |
| RIDADR |
UN 3077 9 / PGIII |
| WGK Germany |
2 |
| RTECS |
LZ6500000 |
| F |
3-10 |
| HS Code |
29389090 |
| Provider |
Language |
| 3-O-(2-O-beta-D-Glucopyranuronosyl-alpha-D-glucopyranuronosyl)-18beta-g lycyrrhetinic acid ammonium salt |
English |
| SigmaAldrich |
English |
| |
| Glycyrrhizic acid ammonium salt Usage And Synthesis |
| Description |
§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques. |
| Chemical Properties |
Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation, followed by neutral- ization with dilute ammonia Monoammonium glycyrrhizinate (C42H62O16NH45H2O) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques. |
| Chemical Properties |
white to slightly yellow powder |
| Uses |
Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl ammatory drugs with which Ammonium Glycyrrhizinate is associated. |
| Uses |
anti-cancer agent |
| Uses |
pharmaceutical excipient, GRAS, sweetener |
| Uses |
Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5-9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings. |
| Anticancer Research |
Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide. |
| Safety Profile |
Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3. |
| Purification Methods |
Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.] |
| |
| Glycyrrhizic acid ammonium salt Preparation Products And Raw materials |
| Raw materials |
Ammonium hydroxide-->LACQUER THINNER-->Glycyrrhizic acid-->DGL |
| Preparation Products |
Ammonium Glycyrrhizinate |
Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on.
Our food additives and food ingredients, especially our Ascorbic Acid (Vitamin C), Acesulfame-K, Aspartame, Citrates, Dextrose, D-Xylose, Erythorbic Acid, Fumaric Acid, Fructose,Maltodextrin, Malic Acid, Monosodium glutamate, Lactic Acid Potassium Sorbate, Sodium Erythorbate, Sodium Cyclamate, Sodium Saccharin, sodium benzoate, Sodium ascorbate, Sorbic Acid, xanthan Gum, Xylitol, Tartaric Acid, I+G, , Vanillin, Sucralose, Stevia and so on, have been exported to more than 60 countries for our good quality products.
Our staff of sales and technical support is available to help you in selecting the right protection for your application as well as to provide you with samples of our products for evaluation. At High Five, we are committed to providing the highest level of customer service, competitive pricing, speedy delivery and a comprehensive, cutting-edge product offering. Our ultimate goal is your satisfaction.
Packing&Shipping
FAQ
Q1.What's the payment terms?
We could accept T/T, L/C, DP payment terms.
Q2.How about the different index of products in same application?
Specifications can be customized according to your application.
Q3.How about the samples of products?
We can provide free samples under 2Kg(not including freight charge).
Q4.How about the price of products?
Our products are chemical synthesis got from underground brine, which is available for a variety of usage. Our products are high purity with good quality, and the price is based on different specification and quantity.
Q5.What's the shelf life for the cargoes?
Our product's shelf life is 2 years, which is based on dry and ventilated storage.
Q6.What's the package of the cargoes?
20kg/25kg woven bags, within plastic bags, or as customized.
Q7.What's the delivery time?
We usually deliver the cargoes within 10~20 days after receiving customer's payment or original L/C.
Q8.Which documents can we supply?
Commercial Invoice, Packing List, Certificate of Analysis, Certificate of Origin (FORM E), Bill of Loading, ISO etc.
The documents will be sent by Express within 24 hours against your full payment.
Q9.Why do you choose us?
We accept safe and diversified payment terms.
We supply a price trend to ensure clients know marketing information in time. We will take charge of 100% responsibility for
quality issue. We strive to create value for each customer we serve by meeting their unique needs and providing solutions to solve their problems and achieve their objectives.
Audited Supplier 
){kind=link}
){kind=link}